Gypenosides Inhibited Invasion and Migration of Human Tongue Cancer SCC4 Cells through Down-regulation of NFκB and Matrix Metalloproteinase-9

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题名:	Gypenosides Inhibited Invasion and Migration of Human Tongue Cancer SCC4 Cells through Down-regulation of NFκB and Matrix Metalloproteinase-9
作者:	呂孔文(Kung-Wen Lu);蔡明俐(Ming-Li Tsai);陳榮洲(Jung-Chou Chen);徐素琴(Shu-Chun);夏德椿(Te-Chun Hsia);林孟葳(Meng-Wei Lin);黃安正(Huang AC);張永賢(Yung-Hsien Chang);葉兆雲(Ip Siu-Wan);呂旭峰(Hsu-Feng Lu);鍾景光(Jing-Gung Chung)*
贡献者:	生命科學院生物科技學系;中國附醫醫學研究部
关键词:	Gypenosides;cell invasion and migration;NFκB;MMP-2;MMP-9
日期:	2008-03
上传时间:	2009-08-25 14:39:53 (UTC+8)
摘要:	Gypenosides (Gyp), components of Gynostemma pentaphyllum Makino, were found to induce suppression of human tongue squamous cell carcinoma SCC4 cell growth and induce apoptosis in response to overexpression of reactive oxygen species, calcium (Ca+2) and to decrease mitochondrial membrane potential in vitro. In this study, the effect of Gyp on cell migration and invasion of human tongue SCC4 cells was examined. SCC4 cells treated in vitro with Gyp migrated and invaded less than cells treated with phosphate-buffered saline (PBS) as a control. Gyp inhibited migration and invasion by down-regulating the production of RAS, NFÎB, COX2, ERK1/2 and MMP-9 relative to PBS only. These results show that Gyp inhibits invasion and migration of human tongue SCC4 cells by down-regulating proteins associated with these processes, resulting in reduced metastasis.
關聯:	ANTICANCER RESEARCH 28(2A )1093 ~1100
显示于类别:	[生物科技學系暨碩士班] 期刊論文

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