Mechanism of heme oxygenase-1 gene induction by quercetin in rat aortic smooth muscle cells.

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Title:	Mechanism of heme oxygenase-1 gene induction by quercetin in rat aortic smooth muscle cells.
Authors:	(Lin HC);鄭志鴻(CHENG, TZU-HURNG);(Chen YC);(Juan SH)
Contributors:	生命科學院生物科技學系
Keywords:	Rat aortic smooth muscle cell;Heme oxygenase;Quercetin;Mitogen-activated protein kinase;Extracellular signal-regulated kinase;c-Jun N-terminal kinases
Date:	2004-06
Issue Date:	2009-08-25 14:38:53 (UTC+8)
Abstract:	We previously reported that adenovirus-mediated gene transfer of heme oxygenase-1 (HO-1) inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. This finding implies that HO-1 induction is beneficial for protecting blood vessels. We also found that quercetin, a common polyphenolic compound in foods of plant origin, induces HO-1 expression in RAW264.7 cells. This study was aimed at examining the potency of quercetin as a HO-1 inducer and its regulation in rat aortic smooth muscle cells (RASMCs). We showed that quercetin-induced HO-1 production was in time- and dose-dependent fashions, and that this regulation occurred at both transcription and translation levels. Quercetin increased p38 mitogen-activated protein kinase (p38MAPK), but inhibited extracellular signal-regulated kinase in RASMCs. The level of quercetin-induced HO-1 expression was attenuated by SB202190 (a p38MAPK inhibitor). Taken together from the data in this study, we suggest that quercetin induced HO-1 expression, at least in part, through p38MAPK.
Relation:	PHARMACOLOGY 71(2)107 ~112
Appears in Collections:	[Department of Biological Science and Technology] Journal articles

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