中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/6201
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    題名: Inhibitory effect of trilinolein on angiotensin II-induced cardiomyocyte hypertrophy.
    作者: (Liu JC)、鄭志鴻(CHENG, TZU-HURNG)、(Lee HM)、(Lee WS)、(Shih NL)、(Chen YL)、(Chen JJ)、(Chan P)
    貢獻者: 生命科學院生物科技學系
    關鍵詞: Angiotensin II;Trilinolein;Cardiomyocyte hypertrophy;Reactive oxygen species;MAP (mitogen-activated protein) kinase;β-myosin heavy chain
    日期: 2004-01
    上傳時間: 2009-08-25 14:38:40 (UTC+8)
    摘要: The myocardial protective effects of trilinolein, isolated from the Chinese herb Sanchi (Panax notoginseng), may be related to its antioxidant effects. In the present study, we investigated the effects of trilinolein on angiotensin II-induced cardiomyocyte hypertrophy. Cultured neonatal rat cardiomyocytes were stimulated with angiotensin II, [3H]leucine incorporation and the β-myosin heavy chain promoter activity were examined. We also examined the effects of trilinolein on angiotensin II-induced intracellular reactive oxygen species generation. Trilinolein significantly inhibited angiotensin II-increased protein synthesis, β-myosin heavy chain promoter activity, and intracellular reactive oxygen species generation. Antioxidant N-acetylcysteine also decreased angiotensin II-increased protein synthesis and β-myosin heavy chain promoter activity. Furthermore, trilinolein and N-acetylcysteine decreased angiotensin II- or hydrogen peroxide (H2O2)-activated mitogen-activated protein kinases (MAPKs) phosphorylation, and activator protein-1 (AP-1)- [or nuclear factor-κB (NF-κB)]-reporter activities. These data indicate that trilinolein inhibits angiotensin II-induced cardiomyocyte hypertrophy and β-myosin heavy chain promoter activity via attenuation of reactive oxygen species generation.
    關聯: EUROPEAN JOURNAL OF PHARMACOLOGY 484(1)1 ~8
    顯示於類別:[生物科技學系暨碩士班] 期刊論文

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