Oxidative DNA damage estimated by urinary 8-hydroxydeoxyguanosine: influence of taxi driving, smoking and areca chewing

CMUR > College of Public Health > Graduate Institute of Environmental Medicine > Journal articles > Item 310903500/5951

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/5951

Title:	Oxidative DNA damage estimated by urinary 8-hydroxydeoxyguanosine: influence of taxi driving, smoking and areca chewing
Authors:	莊淳于(Chun-Yu Chuang);李珍珍(Chen-Chen Lee);(Yu-Kang Chang);宋鴻樟(Fung-Chang Sung)*
Contributors:	公共衛生學院環境醫學研究所
Keywords:	Taxi drivers;Nitrogen oxides;Polycyclic aromatic hydrocarbons;1-Hydroxypyrene;Oxidative DNA damage;8-Hydroxydeoxyguanosine
Date:	2003
Issue Date:	2009-08-25 14:30:01 (UTC+8)
Abstract:	Nitrogen oxides (NOx) and polycyclic aromatic hydrocarbons are common air pollutants generated from automobile exhaust and cigarette smoke. This study was to investigate urinary 8-hydroxydeoxyguanosine (8-OHdG) as an effective biomarker on DNA damage from traffic exhaust and/or smoking in exposed and non-exposed individuals. With subject consents, the levels of plasma NOx, urinary 1-hydroxypyrene (1-OHP) and 8-OHdG were determined for 95 male taxi drivers and 75 male community residents as the reference group. After adjusting for associate variables, there was a significant correlation between the levels of urinary 8-OHdG and 1-OHP but not NOx. The average level of urinary 8-OHdG was significantly higher in drivers than in community men (13.4 ± 4.7 vs. 11.5 ± 4.7 μg/g creatinine in mean ± standard deviation). Compared with non-smoking community men, the multivariate logistic regression showed that the odds ratios (OR) of having elevated levels of urinary 8-OHdG (greater than the overall median value, 12.1 μg/g creatinine) were 6.6 (95% confidence interval (CI)=2.1–20.8) for smoking community men, 5.0 (95% CI=1.7–14.7) for non-smoking taxi drivers and 4.6 (95% CI=1.4–15.0) for smoking taxi drivers. Higher risk was also observed for areca quid chewers compared with non-chewers (OR=1.6; 95% CI=1.1–3.6). In conclusion, taxi driving and smoking may contribute independently to elevated DNA damage using urinary 8-OHdG levels as a sensitive biomarker. This effect is most potent on heavy smokers.
Relation:	CHEMOSPHERE (52)1163~1171
Appears in Collections:	[Graduate Institute of Environmental Medicine] Journal articles

Files in This Item:

File	Size	Format
	0Kb	Unknown	434	View/Open

Loading...