Interactive Effects of Lifetime Alcohol Consumption and Alcohol and Aldehyde Dehydrogenase Polymorphisms on Esophageal Risks

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Title:	Interactive Effects of Lifetime Alcohol Consumption and Alcohol and Aldehyde Dehydrogenase Polymorphisms on Esophageal Risks
Authors:	(Yun-Ju Chen);(Deng-Chyang Wu);(Chien-Hung Lee);(Chen-I Wu);(Jang-Ming Lee);(Yih-Gang Goan);(Shu-Pin Huang);林正介(Lin,Cheng-Chieh);李采娟(Tsai-Chung Li);吳明蒼*
Contributors:	公共衛生學院環境醫學研究所
Keywords:	esophageal cancer;alcohol;alcohol dehydrogenase;aldehyde dehydrogenase;genetic polymorphisms
Date:	2006-12
Issue Date:	2009-08-25 14:29:42 (UTC+8)
Abstract:	In our previous study, we found that polymorphisms of alcohol and aldehyde dehydrogenase (ADH1B and ALDH2) are important risks for esophageal squamous cell carcinoma in a Taiwanese population. In this study, we increased the sample size to investigate the modifying effect of lifetime alcohol consumption on the association between ADH1B and ALDH2 genotypes and the risks of esophageal cancer. A multicenter hospital-based case-control study was conducted between August 2000 and June 2004. Three hundred and thirty newly-diagnosed esophageal squamous cell carcinoma patients and 592 controls were recruited from National Taiwan University Hospital in Taipei and Kaohsiung Veterans General Hospital and Kaohsiung Medical University Hospital in Kaohsiung, Taiwan. Controls were matched to the case patients by gender and age within 4 years (case:control = 1:1-4). Polymorphisms of ADH1B and ALDH2 were genotyped by the method of PCR-RFLP. Individuals with ADH1B1/1 genotype had a 3.99-fold risk (95% CI = 2.13-7.48) of developing esophageal cancer, compared with those with ADH1B2/2 genotype, after adjusted for appropriate covariates. Individuals with ALDH21/2 and ALDH22/2 had 4.99-fold risk (95% CI = 3.11-7.99) and 4.24-fold risk (95% CI = 1.52-11.84), respectively, of developing esophageal cancer, compared with those with ALDH21/1, after adjusted for appropriate covariates. We also found a modifying effect of lifetime alcoholic consumption on the association between genotypes of ADH1B and ALDH2 on esophageal cancer risk. These results suggest that ADH1B and ALDH2 polymorphisms play a pivotal role on esophageal cancer and that the effect of these polymorphisms was modified by the amount of alcohol consumed.
Relation:	INTERNATIONAL JOURNAL OF CANCER 119(12 )2827 ~2831
Appears in Collections:	[Graduate Institute of Environmental Medicine] Journal articles

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