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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/5906
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| 題名: | Low birth weight and high birth weight infants are both at an increased risk to have type 2 diabetes among school children in Taiwan |
| 作者: | (Wei JN);宋鴻樟(Fung-Chang Sung);(Li CY);鄭雅靜(Ya-Chang Cheng);(Lin RS);(Lin CC);(Chiang CC);(Chuang LM) |
| 貢獻者: | 公共衛生學院環境醫學研究所 |
| 關鍵詞: | ADA, American Diabetes Association;CFH, Chinese Foundation of Health;DBP, diastolic blood pressure;FPG, fasting plasma glucose;GDM, gestational diabetes mellitus;HNF, hepatocyte nuclear factor;IFG, impaired fasting glycemia;NFG, normal fasting glycemia;OR, odds ratio;SBP, systolic blood pressure;SES, socioeconomic status |
| 日期: | 2003-02 |
| 上傳時間: | 2009-08-25 14:29:22 (UTC+8) |
| 摘要: | OBJECTIVE—To study the effect of birth weight on risk of type 2 diabetes in the schoolchildren in Taiwan.
RESEARCH DESIGN AND METHODS—From 1992 to 1997, all schoolchildren aged 6–18 years were screened for diabetes in Taiwan Province. This cohort consisted of 1,966 patients with diabetes and 1,780 randomly selected subjects with normal fasting glycemia (NFG). Questionnaire interviewing was designed to classify diabetes. The birth weight was obtained from the Taiwan’s Birth Registry. After merging the data, there were 978 subjects, including 429 with type 2 diabetes and 549 with of NFG enrolled in the present analyses.
RESULTS—The odds ratios (95% CI) for type 2 diabetes, after adjusting age, sex, BMI, family history of diabetes, and socioeconomic status, were 2.91 (1.25–6.76) for children with low birth weight (<2,500 g) and 1.78 (1.04–3.06) for those with high birth weight (≥4,000 g) when compared with the referent group (birth weight 3,000–3,499 g). The risk of diabetes was still 64% higher in the high birth weight group [odds ratio (OR) 1.64 (95% CI 0.91–2.96)], even after adjustment for gestational diabetes mellitus (GDM). Patients with type 2 diabetes who were born with high birth weight were more likely to have a higher BMI and diastolic blood pressure as well as a higher family history of diabetes compared with those with low birth weight.
CONCLUSIONS—A U-shaped relationship between birth weight and risk of type 2 diabetes was found in the schoolchildren aged 6–18 years in Taiwan. Schoolchildren with type 2 diabetes who were born with low birth weight had different metabolic phenotypes compared with those born with high birth weight. |
| 關聯: | DIABETES CARE 26(2)343~348 |
| 顯示於類別: | [環境醫學研究所(已停用)] 期刊論文
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