臺灣市售澤蘭與佩蘭藥材之鑑定研究

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Title:	臺灣市售澤蘭與佩蘭藥材之鑑定研究 Identification of Lycopi Herba (Ze Lan) and Eupatorii Herba (Pei Lan) in Taiwan
Authors:	邱順聰;Shun-Tsung Chiu
Contributors:	中國藥學暨中藥資源學系碩士班
Keywords:	澤蘭;佩蘭;地筍;地瓜兒苗;蘭草;Lycopi Herba;Ze Lan;Eupatorii Herba;Pei Lan
Date:	2019-08-30
Issue Date:	2019-11-08 11:15:28 (UTC+8)
Publisher:	中國醫藥大學
Abstract:	澤蘭始載於《神農本草經》，列為中品，其基源為唇形科(Labiatae)植物毛葉地瓜兒苗 Lycopus lucidus Turczaninow var. hirtus Regel 及地瓜兒苗 Lycopus lucidus Turczaninow 的乾燥莖葉，入肝、脾二經，具有活血化瘀、利尿、消腫等功效，方劑有七釐散《新傷續斷方》、四制香附丸《景岳全書》、澤蘭丸《外臺秘要》、柏子仁丸《婦人大全良方》及澤蘭湯、承澤丸《備急千金要方》等。佩蘭始載於《神農本草經》列為上品，原名為「蘭草」，歷代以來澤蘭常與佩蘭相互混淆。至《本草綱目》時始分澤蘭與蘭草為一類二種。蘭草自《本草從新》後乃稱佩蘭，為菊科(Compositae)植物佩蘭Eupatorium fortunei Turcz.的乾燥全草，歸脾，胃，肺經，主治療濕熱內蘊，脾胃內熱口甘，方劑有蘭草湯《黃帝內經·素問》。臺灣的藥材多自中國進口，常有誤用或混用的問題。為瞭解臺灣中藥材市場，澤蘭與佩蘭藥材的使用情況，本研究採用隨機取樣方式購買臺灣北、中、南的中藥房與藥局，收集了數十批藥材。通過對外觀和組織學顯微鑑別、薄層層析法(TLC)與高效液相層析法(HPLC)分析比較並進行雜質檢查(乾燥減重、總灰分、酸不溶性灰分、二氧化硫)與含量測定(稀乙醇抽提物、水抽提物)等鑑定方法對藥材進行探討。實驗結果澤蘭的誤用率高達80％，居然多以佩蘭代用澤蘭，這將直接影響民眾的用藥安全性與有效性。本研究希望能提供中醫藥從業人員對中藥材澤蘭與佩蘭的的品質差異性做進一步的瞭解，以避免重複錯用，提升中醫藥品質，這也是本研究的主要目的。 Zelan was first published in the Shennong Herbal Medicine Classic and was classified as a middle-class . Its origins are Lycopus lucidus Turczaninow var.hirtus Regel and Labiatae plants . The dried stems and leaves of Lycopus lucidus Turczaninow seedlings enter the liver and spleen meridians . It has the functions of activating blood circulation and removing blood stasis , diuresis and detumescence . The prescription is Qili San "New Injury Dipse Formula"、Four Xiangfu Pills , Jingyue Quanshu、Zelan Pill Outside Secret Essentials、Baiziren Pill "All Good Prescriptions for Women's Congress"、Zelan Decoction, Chengze Pills , etc . Peilan was first listed as the top grade in Shennong Herbal Medicine Classic . Originally known as "orchid grass", Zelan has often been confused with Peilan in past dynasties . At the time of Compendium of Materia Medica, Zelan and Orchid were classified as two species . The orchid grass is called Peilan after "Materia Medica is New" . For Compositae plant Eupatorium fortunei Turcz .Returning to the spleen , stomach and lung meridians , The main treatment is damp-heat connotation , spleen-stomach heat and sweet taste . The prescription is Lancao Tang , Huangdi Neijing Suwen . Taiwan's medicines are mostly imported from China and often have problems of misuse or misuse . In order to understand the market of traditional Chinese medicine in Taiwan , The use of Zelan and Peilan medicinal materials . In this study , random sampling was used to purchase Taiwan . Chinese pharmacies and pharmacies in North , Central and South China .Dozens of medicinal materials were collected . Through microscopic identification of appearance and histology , Thin Layer Chromatography (TLC) and Analysis and comparison with high performance liquid chromatography (HPLC) And carry out impurity inspection (Drying weight loss , total ash , acid insoluble ash , sulfur ioxide) And content determination (dilute ethanol extract , water extract) The identification methods were discussed . The misuse rate of Zelan was as high as 80% . It's surprising that Peilan is mostly used instead of Zelan . This will directly affect the safety and effectiveness of drug use . The purpose of this study is to provide quality differences between Zelan and Peilan among practitioners of traditional Chinese medicine . For further understanding , To avoid repeated misuse and improve the quality of traditional Chinese medicine , This is also the main purpose of this study .
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