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    Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/58508


    Title: 遠紅外線照射對腦低灌流大鼠學習-記憶效用之研究
    Effect of far-infrared ray irradiation on learning-memory in rats with cerebral hypo-perfusion
    Authors: 林玉婷;Yu-Ting Lin
    Contributors: 針灸研究所碩士班
    Keywords: 遠紅外線;腦低灌流;學習-記憶;Far infrared ray;Cerebral hypoperfusion;Learning-memory
    Date: 2018-08-21
    Issue Date: 2018-12-25 10:00:07 (UTC+8)
    Publisher: 中國醫藥大學
    Abstract: 背景:
    遠紅外線照射可以產生熱和非熱的效應，也能增加大鼠皮膚的微循環。我們假設遠紅外線照射大鼠可以增加腦低灌流大鼠的循環，進而改善學習-記憶。
    目的：
    探討遠紅外線照射對腦低灌流大鼠學習-記憶的效用。
    方法：
    將雄性wistar大鼠兩側頸總動脈永久結紮3週建立一個腦低灌流大鼠。實驗組施予遠紅外線照射，每週5次，一次30分鐘， 連續3週，而控制組則使用假遠紅外線照射。使用被動迴避試驗，觀察大鼠的學習-記憶。最後將大鼠犧牲取下腦部組織切片，分別以NR1、TrkA、dopamine 1 和dopamine 5 receptors進行海馬區免疫組織化學染色（immunohistochemistry stain, IHC）並統計分析。
    結果：
    被動迴避試驗的記憶時間及NR1、TrkA、dopamine 1 和dopamine 5 receptors免疫陽性染色細胞，實驗組和對照組沒有顯著的差異（all p > 0.05）。
    結論：
    遠紅外線照射3週不能改變腦低灌流大鼠學習記憶和改變NR1、TrkA、dopamine 1 和dopamine 5 receptors免疫陽性染色細胞，因此遠紅外線外線照射對腦低灌流大鼠的作用有必要更進一步的研究。
    Background:
    Far-infrared ray irradiation can produce thermal and non-thermal effects, and also can increase microcirculation in rat skin. We hypothesize that far-infrared irradiation can increase the circulation in rats with cerebral hypoperfusion, and improves learning-memory.
    Objective:
    The present study was to investigate the effect of the far-infrared ray irradiation on learning-memory in rats with cerebral hypoperfusion.
    Methods:
    We established a cerebral hypoperfusion model by ligating both common carotid arteries in male Wistar rats for 3 weeks. The far-infrared ray irradiation was done five times per week, each time was 30 minutes for 3 weeks in the experiment group, while the sham far-infrared ray irradiation was done in the control group. Using a passive avoidance test to investigate learning-memory. Finally, the rats were sacrificed and the brains were removed for immunohistochemistry staining (IHC) of NR1, TrkA, dopamine 1 and dopamine 5 receptors in the hippocampus, and then statistical analyses.
    Results:
    The memory time of passive avoidance test and the immunoreactive cell counts of NR1, TrkA, dopamine 1 and dopamine 5 receptors were not significant difference between control and experimental groups (all p > 0.05).
    Conclusion:
    The far infrared ray irradiation for 3 weeks did not change learning-memory function, and also did not change the immunoreactive counts of NR1, TrkA, dopamine 1 and dopamine 5 receptors. Therefore, the effect of the far infrared ray irradiation on cerebral hypoperfusion need further study.
    Appears in Collections:[Graduate Institute of Acupuncture Science] Theses & dissertations

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