中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/58299
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    Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/58299


    Title: 利用α-Halo-N-arylacetamides有效合成N-arylformamide 類化合物之研究探討
    Effective Synthesis of N-arylformamide from α-Halo-N-arylacetamides
    Authors: 江坤恆;Kun-Heng Chiang
    Contributors: 藥學系碩士班
    Keywords: N-芳香基甲醯胺;甲醯化反應;N-arylformamide;formamidation
    Date: 2017-06-30
    Issue Date: 2018-01-15 09:31:27 (UTC+8)
    Publisher: 中國醫藥大學
    Abstract: 本論文研究使用α-iodo-N-arylacetamides和formamide，成功簡易合成出N-arylformamide類化合物。本方法可適用於含有推、拉電子基團的α-iodo-N-arylacetamides，包含N-(benzo[1,3-d]dioxol-5-yl)-2-iodoacetamide、2-iodo-N-(pyridin-2-yl)acetamide、和2-iodo-N-(naphthalen-1-yl)acetamide，其合成產率約65–94%。並報告相關反應機轉以說明其反應進行過程。
    A convenient synthetic method for N-arylformamide derivatives was successfully developed by reacting α-iodo-N-arylacetamides with formamide. This method was applicable to α-iodo-N-arylacetamide substrates bearing electron-donating or electron-withdrawing groups, N-(benzo[1,3-d]dioxol-5-yl)-2-iodoacetamide, 2-iodo-N-(pyridin-2-yl)acetamide, and 2-iodo-N-(naphthalen-1-yl)acetamide to give the corresponding N-arylformamides in moderate to excellent yields. A plausible mechanism was proposed to account for the new transformation.
    Appears in Collections:[School of Pharmacy/Master Degree Program, Ph. D program] Theses & dissertations

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