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    Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/58153


    Title: 電針華陀夾脊穴治療神經性痛的療效與機轉
    Effects and Mechanisms of Electroacupuncture at Hua Tuo Jia Ji Points on Neuropathic Pain in Rats
    Authors: 江曉薇;Siao-Wei Jiang
    Contributors: 中獸醫碩士學位學程
    Keywords: CCI;電針;華佗夾脊穴;EA;Hua Tuo Jia Ji
    Date: 2017-07-26
    Issue Date: 2018-01-15 09:03:59 (UTC+8)
    Publisher: 中國醫藥大學
    Abstract: 　　實驗動物慢性壓迫性損傷模型（Chronic constriction injury model, CCI model）模擬人神經性痛痛覺敏感（hyperalgesia）和痛覺超敏（allodynia）之症狀。本研究目的為電針華佗夾脊穴治療神經性痛是否能緩解神經性疼痛，並探討其可能的治療機轉。本研究實驗設計為針對Sprague-Dawley（SD）大鼠右後肢坐骨神經進行CCI模型，並隨機分組偽電針組、2 Hz電針治療組及15 Hz電針治療組，在確認CCI模型成功後，於術後第六天開始進行連續三天電針治療，並於每次治療後隔天進行冷板試驗、輻射熱試驗及von Frey 試驗，治療結束即將大鼠犧牲，以西方墨點法（Western blot）針對大鼠脊髓神經及大腦皮質尋找可能的止痛機轉。結果顯示：(1) 2Hz電針治療組對於熱輻射及von Frey 試驗有緩解疼痛的效果；(2) 15Hz電針治療von Frey 試驗有緩解疼痛的療效；(3)三組之間於大腦皮質及脊髓的Adenosine A1 Receptor（A1R）、α subunit of γ-aminobutyric acid（GABAA） receptor、Metabotropic Glutamate Receptor 3（mGluR3）、Transient receptor potential cation channel, subfamily V, member 1（TRPV1）及Transient receptor potential cation channel subfamily V member 4（TRPV4） 都沒有顯著差異。
    華佗夾脊穴2Hz和15Hz電針治療可以減少部分CCI model誘發神經性痛，但其作用機轉須進一步的研究。
    Chronic constriction injury (CCI) model ’s similar to hyperalgesia in painful human peripheral neuropathies, like hyperalgesia and allodynia. In our study, we designed electrical acupuncture at bilateral L4 and L6 of Hua Tuo Jia Ji points (EX-B2) as treatment to neuropathic pain. Eighteen SD rats assigned randomly to three groups: sham group, 2 Hz electronic-acupuncture(EA) group, and 15 Hz EA group. The rats accepted acupuncture as treatment on the 6th day after surgery. The radiant heat, cold plate leg lift, and von Frey tests were conducted to elevate the effects of treatments before and each day after acupuncture and then sacrificed on the 9th day after surgery. Then we tried to find the mechanism by western blot with protein of brain and spinal cord. The results: (1) 2 Hz EA can alleviate pain of thermal hyperalgesia and prinprick hyperalgesia; (2) 15 Hz EA can alleviate pain of prinprick hyperalgesia; (3) the adenosine A1 Receptor(A1R), the α subunit of γ-aminobutyric acid (GABAA) receptor, metabotropic Glutamate Receptor 3(mGluR3), transient receptor potential cation channel, subfamily V, member 1(TRPV1) and transient receptor potential cation channel subfamily V member 4(TRPV4) were no significant difference among three groups in the cerebral cortex and spinal cord.

    2Hz and 15H electroacupuncture applied to Hua Tuo Jia Ji points could reduce partly pain-induced by CCI neuropathic pain, and the analgesic mechanisms need further study.
    Appears in Collections:[Master's Program for Traditional Chinese Veterinary Medicine] Theses & dissertations

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