Tumor necrosis factor alpha, CYP 17, urokinase, and interleukin 10 gene polymorphisms in postmenopausal women: correlation to bone mineral density and susceptibility to osteoporosis

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Title:	Tumor necrosis factor alpha, CYP 17, urokinase, and interleukin 10 gene polymorphisms in postmenopausal women: correlation to bone mineral density and susceptibility to osteoporosis
Authors:	(Chen HY);陳慧毅(Huey-Yi Chen);陳汶吉(Chen Wen-Chi);許欽木(Chin-Moo Hsu);蔡輔仁(Fuu-Jen Tsai)*;蔡長海(Chang-Hai Tsai)
Contributors:	中醫學院學士後中醫學系學士班中醫基礎學科;中國附醫兒童醫學中心小兒遺傳科
Keywords:	Tumor necrosis factor α;CYP 17;Urokinase;Interleukin 10;Bone mineral density;Polymerase chain reaction;Restriction fragment length polymorphism;Postmenopausal women;Osteoporosis
Date:	2005-09
Issue Date:	2009-08-24 15:02:29 (UTC+8)
Abstract:	Objective: Osteoporosis is a common disorder with a strong genetic component. We investigated the correlations between bone mineral density (BMD) and four gene polymorphisms (−308G>A tumor necrosis factor α (TNF-α), −34T>C CYP 17, 141T>C urokinase, and −627C>A interleukin 10 (IL-10) promoter), and their relationship to osteoporosis in postmenopausal women. Study design: These polymorphisms were determined using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) analysis. BMD of the lumbar spine and proximal femur were measured using dual-energy X-ray absorptiometry. Results: The prevalence of each genotype was as follows: (1) 79.3% A/A, 16.6% A/G, and 4.1% G/G in −308G>A TNF-α; (2) 18.9% T/T, 52.1% T/C, and 29% C/C in −34T>C CYP 17; (3) 86.4% C/C and 13.6% C/T in 141T>C urokinase; (4) 46.2% A/A, 45% A/C, and 8.8% C/C in −627C>A IL-10 promoter. Subjects with genotype C/C in −627C>A IL-10 promoter had lower BMD values and a significantly greater risk for osteoporosis (OR 8.1, 95% CI 1.5–42.8) at the lumbar spine compared with subjects with genotype A/C in −627C>A IL-10 promoter, after adjustment for potential confounders. Conclusion: The RsaI IL-10 promoter gene polymorphism is associated with reduced BMD and predisposes women to osteoporosis at the lumbar spine.
Relation:	EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY 122(1 )73 ~78
Appears in Collections:	[Graduate Institute of Acupuncture Science] Journal articles

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