Simultaneously Evaluating the Effects of One-week Fluticasone Propionate Inhalation Therapy on Lung Ventilation and Permeability in Children with Asthma

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Title:	Simultaneously Evaluating the Effects of One-week Fluticasone Propionate Inhalation Therapy on Lung Ventilation and Permeability in Children with Asthma
Authors:	(An-Chyi Chen);蔡輔仁(Fuu-Jen Tsai);蔡長海(Chang-Hai Tsai);林正介(Cheng-Chieh Lin);李正淳(Cheng-Chun Lee);高嘉鴻(Chia-Hung Kao)
Contributors:	中醫學院學士後中醫學系學士班中醫基礎學科;中國附醫兒童醫學中心小兒遺傳科
Keywords:	Asthma;Fluticasone propionate inhalation therapy;Tc-99m DTPA radioaerosol;Lung ventilation;Alveolar permeability
Date:	2003
Issue Date:	2009-08-24 15:02:22 (UTC+8)
Abstract:	This study evaluated the effects of fluticasone propionate inhalation therapy on lung ventilation and alveolar permeability by quantitative Tc-99m DTPA radioaerosol inhalation lung scintigraphy in 15 children with asthma. Lung ventilation was evaluated as the distribution percentage (D%) of Tc-99m DTPA radioaerosols in the central, intermediate and peripheral regions of the right lung. Alveolar permeability was measured by the rate of Tc-99m DTPA radioaerosol clearance curve from the peripheral alveoli of the right lung and represented as slope. The D% and slopes were calculated before and after one-week inhalation therapy (100 µg fluticasone propionate two times daily for one-week) to evaluate the effects of inhalation therapy on lung ventilation and alveolar permeability. The preliminary results revealed statistically significantly improved lung ventilation but no significant change of alveolar permeability in the right lung after one-week fluticasone propionate inhalation therapy in children with asthma. We suggest that the widely available and noninvasive Tc-99m DTPA radioaerosol inhalation lung scintigraphy can simultaneously evaluate lung ventilation and alveolar permeability in one study and should contribute to any disorder involving both alveoli and airways.
Relation:	MITTEILUNGEN DER OSTERREICHISCHEN GEOGRAPHISCHEN GESELLSCHAFT 181(5 )283 ~289
Appears in Collections:	[Graduate Institute of Acupuncture Science] Journal articles

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