The involvement of serotonin receptors in suanzaorentang-induced sleep alteration

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Title:	The involvement of serotonin receptors in suanzaorentang-induced sleep alteration
Authors:	尹珮璐(Yi PL);林俊邦(Lin CP);蔡崇豪(Chon-Haw Tsai);林昭庚(Jaung-Geng Lin);張芳嘉(Fang-Chia Chang)*
Contributors:	中醫學院針灸研究所
Keywords:	suanzaorentang;non-rapid eye movement sleep (NREMS);rapid eye movement sleep (REMS);serotonin
Date:	2007
Issue Date:	2009-08-24 14:59:59 (UTC+8)
Abstract:	Sedative-hypnotic medications, including benzodiazepines and non-benzodiazepines, are usually prescribed for the insomniac patients; however, the addiction, dependence and adverse effects of those medications have drawn much attention. In contrast, suanzaorentang, a traditional Chinese herb remedy, has been efficiently used for insomnia relief in China, although its mechanism remains unclear. This study was designed to further elucidate the underlying mechanism of suanzaorentang on sleep regulation. One ingredient of suanzaorentang, zizyphi spinosi semen, exhibits binding affinity for serotonin (5-hydroxytryptamine, 5-HT) receptors, 5-HT1A and 5-HT2, and for GABA receptors. Our previous results have implicated that GABAA receptors, but not GABAB, mediate suanzaorentang-induced sleep alteration. In current study we further elucidated the involvement of serotonin. We found that high dose of suanzaorentang (4 g/kg/2 ml) significantly increased non-rapid eye movement sleep (NREMS) when comparing to that obtained after administering starch placebo, although placebo at dose of 4 g/kg also enhanced NREMS comparing with that obtained from baseline recording. Rapid eye movement sleep (REMS) was not altered. Administration of either 5-HT1A antagonist (NAN-190), 5-HT2 antagonist (ketanserin) or 5-HT3 antagonist (3-(4-Allylpiperazin-1-yl)-2-quinoxalinecarbonitrile) blocked suanzaorentang-induced NREMS increase. These results implicate the hypnotic effect of suanzaorentang and its effects may be mediated through serotonergic activation, in addition to GABAergic system.
Relation:	JOURNAL OF BIOMEDICAL SCIENCE 14(6)829 ~840
Appears in Collections:	[Graduate Institute of Acupuncture Science] Journal articles

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