Aging specifically impairs amnesiac-dependent memory in Drosophila.

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Title:	Aging specifically impairs amnesiac-dependent memory in Drosophila.
Authors:	(Tamura T);(Chiang AS);(Ito N);劉心萍;(Horiuchi J);(Tully T);(Saitoe M)*
Contributors:	中醫學院針灸研究所
Date:	2003-12
Issue Date:	2009-08-24 14:59:54 (UTC+8)
Abstract:	Age-related memory impairment (AMI) is observed in many species. However, it is uncertain whether AMI results from a specific or a nonspecific decay in memory processing. In Drosophila, memory acquired after a single olfactory conditioning paradigm has three distinct phases: short-term memory (STM), middle-term memory (MTM), and longer-lasting anesthesia-resistant memory (ARM). Here, we demonstrate that age-related defects in olfactory memory are identical to those of the MTM mutant amnesiac (amn). Furthermore, amn flies do not exhibit an age-dependent decrease in memory, in contrast to other memory mutants. The absence of AMI in amn flies is restored by expression of an amn transgene predominantly in DPM cells. Thus, we propose that AMI in flies results from a specific decrease in amn-dependent MTM.
Relation:	NEURON 40(5)1003~1011
Appears in Collections:	[Graduate Institute of Acupuncture Science] Journal articles

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