Ameliorative effect of four prescriptions of traditional Chinese medicine on α-Naphthylisothiocynate and carbon tetrachloride induced yoxicity in rats

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Title:	Ameliorative effect of four prescriptions of traditional Chinese medicine on α-Naphthylisothiocynate and carbon tetrachloride induced yoxicity in rats
Authors:	(Chin-Chuan Tsai);高尚德(Shung-Te Kao);(Chao-Tien Hsu);(Chun-Ching Lin);(Jaung-Geng Lin)
Contributors:	中醫學院中醫學系學士班中醫內科學科;中國附醫中醫內科
Date:	1997
Issue Date:	2009-08-24 14:50:15 (UTC+8)
Abstract:	Syh-Mo-Yin (SMY), Guizhi-Fuling-Wan (GFW), Shieh-Qing-Wan (SQW) and Syh-Nih-San (SNS) are prescriptions of Traditional Chinese Medicine (TCM) for liver disease. The effects of these four prescriptions against experimental liver injury induced by alpha-Naphthylisothiocyanate (ANIT) and carbon tetrachloride (CCl4) were studied. Rats treated with ANIT (100 mg/kg) exhibited elevations of serum total bilirubin (TBI), alkaline phosphatase (ALP), glutamate-oxalatetransaminase (sGOT) and glutamate-pyruvate-transminase (sGPT) as well as cholestasis and parenchymanecrosis. In rats receiving SMY, SQW and SNS treatment after ANIT challenged, the biochemical and morphological parameters of liver injury were significantly reduce. Elevated lipid peroxidation (LPO) level in liver tissue, associated with an increase in serum GOT and GPT level, was observed in CCl4-treated rats. Treatment with these four prescriptions on CCl4-induced liver injury rats showed a remarkable hepatoprotective effect. A significant decrease in peroxidative level suggested that these prescriptions have anti free radical properties.
Relation:	AMERICAN JOURNAL OF CHINESE MEDICINE 25(2)185 ~196
Appears in Collections:	[School of Chinese Medicine] Journal articles

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