The Proline Form of p53 Codon 72 Polymorphism is Associated with Endometriosis

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中醫學院 > 中醫學系暨碩博班 > 期刊論文 > Item 310903500/5565

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/5565

题名:	The Proline Form of p53 Codon 72 Polymorphism is Associated with Endometriosis
作者:	(Chi-Chen Chang);謝耀元;蔡輔仁(Fuu-Jen Tsai);蔡長海(Chang-Hai Tsai);(Horng-Der Tsai);林正介(Cheng-Chieh Lin)
贡献者:	中醫學院中醫學系學士班中醫內科學科
关键词:	Arginine form;endometriosis;polymorphism;proline form;p53
日期:	2002
上传时间:	2009-08-24 14:50:07 (UTC+8)
摘要:	Objective: To evaluate the association between endometriosis and the p53 polymorphism. Design: Prospective study. Setting: Department of gynecology and genetics in a medical center. Patient(s): Women with and without endometriosis. Intervention(s): Women were categorized as having moderate or severe endometriosis (n = 118) or no endometriosis (n = 140). Main Outcome Measure(s): Polymerase chain reaction was used to detect p53 codon 72 polymorphisms (arginine homozygosity, heterozygosity, and proline homozygosity). Associations between endometriosis and p53 polymorphisms were evaluated. Result(s): The distributions of different p53 polymorphisms differed significantly between groups. The respective proportions of arginine homozygotes, heterozygotes, and proline homozygotes were 10.2%, 66.9%, and 22.9% in the group with endometriosis and 30.7%, 50%, and 19.3% in the group without endometriosis. Conclusion(s): Endometriosis is associated with p53 polymorphism. p53 arginine homozygotes have lower risk for endometriosis. Heterozygotes and proline homozygotes have higher risk for endometriosis.
關聯:	FERTILITY AND STERILITY77(1):43~45
显示于类别:	[中醫學系暨碩博班] 期刊論文

文件中的档案:

档案	大小	格式	浏览次数
	0Kb	Unknown	530	检视/开启

在CMUR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....