Relationship between San-Huang-Xie-Xin-Tang and its herbal components on the gene expression profiles in HepG2 cells.

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中醫學院 > 中國醫學研究所 > 期刊論文 > Item 310903500/5477

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题名:	Relationship between San-Huang-Xie-Xin-Tang and its herbal components on the gene expression profiles in HepG2 cells.
作者:	鄭文裕(Wen-Yu Cheng);吳世祿(Shih-Lu Wu);項千芸(Chien-Yun Hsiang);李佳橙(Chia-Cheng Li);賴東淵(Tung-Yuan Lai);羅欣宜(Hsin-Yi Lo);沈偉舜(Wei-Shuen Shen);李昌諴(Chang-Hsien Lee);陳兆群(Jaw-Chyun Chen);吳琇卿(Wu,Hsiu-Ching);侯庭鏞(Tin-Yun Ho)*
贡献者:	中醫學院中國醫學研究所
关键词:	San-Huang-Xie-Xin-Tang;Microarray;p53
日期:	2008-07
上传时间:	2009-08-24 14:47:12 (UTC+8)
摘要:	Traditional Chinese medicine (TCM) has been used for thousands of years. Most Chinese herbal formulae consist of several herbal components and have been used to treat various diseases. However, the mechanisms of most formulae and the relationship between formulae and their components remain to be elucidated. Here we analyzed the putative mechanism of San-Huang-Xie-Xin-Tang (SHXXT) and defined the relationship between SHXXT and its herbal components by microarray technique. HepG2 cells were treated with SHXXT or its components and the gene expression profiles were analyzed by DNA microarray. Gene set enrichment analysis indicated that SHXXT and its components displayed a unique anti-proliferation pattern via p53 signaling, p53 activated, and DNA damage signaling pathways in HepG2 cells. Network analysis showed that most genes were regulated by one molecule, p53. In addition, hierarchical clustering analysis showed that Rhizoma Coptis shared a similar gene expression profile with SHXXT. These findings may explain why Rhizoma Coptis is the principle herb that exerts the major effect in the herbal formula, SHXXT. Moreover, this is the first report to reveal the relationship between formulae and their herbal components in TCM by microarray and bioinformatics tools.
關聯:	AMERICAN JOURNAL OF CHINESE MEDICINE 36(4)783~797
显示于类别:	[中國醫學研究所] 期刊論文

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