Eriobotrya japonica leaf and its triterpenes inhibited lipopolysaccharide-induced cytokines and inducible enzyme production via the nuclear factor-κB signaling pathway in lung epithelial cells

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中醫學院 > 中國醫學研究所 > 期刊論文 > Item 310903500/5476

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/5476

题名:	Eriobotrya japonica leaf and its triterpenes inhibited lipopolysaccharide-induced cytokines and inducible enzyme production via the nuclear factor-κB signaling pathway in lung epithelial cells
作者:	李昌諴(Chang-Hsien Lee);吳世祿(Shih-Lu Wu);陳兆群(Jaw-Chyun Chen);李佳橙(Chia-Cheng Li);羅欣宜(Hsin-Yi Lo);鄭文裕(Wen-Yu Cheng);林昭庚(Jaung-Geng Lin);張永賢(Yung-Hsien Chang);項千芸(Chien-Yun Hsiang);侯庭鏞(Tin-Yun Ho)
贡献者:	中醫學院中國醫學研究所
关键词:	Eriobotrya japonica;Ursolic Acid;Lung Inflammation;Nuclear Factor-κB
日期:	2008-11
上传时间:	2009-08-24 14:47:12 (UTC+8)
摘要:	Pulmonary inflammation is a characteristic of many lung diseases. Increased levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and proinflammatory cytokines, such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and IL-8, have been correlated with lung inflammation. In this study, we used lipopolysaccharide (LPS) to induce iNOS, COX-2, and cytokines (TNF-α, IL-1β, and IL-8) productions in human lung epithelial cells (A-549). Leaf of Eriobotrya japonica (Pi-Pa-Ye, PPY), a traditional Chinese medicine for the treatment of pulmonary inflammatory diseases, was capable of suppressing LPS-induced cytokine productions in a dose-dependent manner. Moreover, the suppression of PPY on the cytokine productions resulted from the inhibition of inhibitory κB-α phosphorylation and nuclear factor-κB (NF-κB) activation. Analysis of the anti-inflammatory effects of ursolic acid and oleanolic acid, the triterpene compounds present in PPY, showed that ursolic acid significantly inhibited LPS-induced IL-8 production, NF-κB activation, and iNOS mRNA expression, whereas oleanolic acid did not have these effects. In conclusion, our findings suggested the potential mechanisms of PPY and its active component, ursolic acid, in the treatment of pulmonary inflammation.
關聯:	AMERICAN JOURNAL OF CHINESE MEDICINE 36(6 )1185 ~1198
显示于类别:	[中國醫學研究所] 期刊論文

文件中的档案:

档案	大小	格式	浏览次数
	58Kb	Unknown	557	检视/开启

在CMUR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....