Ginger and its bioactive component inhibit enterotoxigenic Escherichia coli heat-labile enterotoxin-induced diarrhea in mice

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Title:	Ginger and its bioactive component inhibit enterotoxigenic Escherichia coli heat-labile enterotoxin-induced diarrhea in mice
Authors:	陳兆群(Jaw-Chyun Chen);黃麗嬌(Li-Jiau Huang);吳世祿(Shih-Lu Wu);郭盛助(Sheng-Chu Kuo);侯庭鏞(Tin-Yun Ho);項千芸(Chien-Yun Hsiang)
Contributors:	中醫學院中國醫學研究所
Date:	2007-10
Issue Date:	2009-08-24 14:47:08 (UTC+8)
Abstract:	Ginger is one of the most commonly used fresh herbs and spices. Enterotoxigenic Escherichia coli heat-labile enterotoxin (LT)-induced diarrhea is the leading cause of infant death in developing countries. In this study, we demonstrated that ginger significantly blocked the binding of LT to cell-surface receptor GM1, resulting in the inhibition of fluid accumulation in the closed ileal loops of mice. Biological-activity-guided searching for active components showed that zingerone (vanillylacetone) was the likely active constituent responsible for the antidiarrheal efficacy of ginger. Further analysis of chemically synthesized zingerone derivatives revealed that compound 31 (2-[(4-methoxybenzyl)oxy]benzoic acid) significantly suppressed LT-induced diarrhea in mice via an excellent surface complementarity with the B subunits of LT. In conclusion, our findings provide evidence that ginger and its derivatives may be effective herbal supplements for the clinical treatment of enterotoxigenic Escherichia coli diarrhea.
Relation:	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 55(21)8390~8397
Appears in Collections:	[Graduate Institute of Chinese Medical Science] Journal articles

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