中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/5449
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    請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/5449


    題名: Sulfotransferase 1A2*2 is a risk factor for early-onset breast cancer
    作者: 侯明峰(Ming-Feng Hou)、陳守棟(Shou-Tung Chen)、陳瑞彰(Jui-Chang Chen)、葉坤土(Kun-Tu Yeh)、李黛苹(Tai-Ping Lee)、陳志玫(Chih-Mei Chen)、施木青(Mu-Chin Shin)、林正介(Cheng-Chieh Lin)、張建國*
    貢獻者: 中國附醫檢驗醫學部
    日期: 2002-11
    上傳時間: 2009-08-24 14:42:53 (UTC+8)
    摘要: The estrogen-signaling pathway plays an important role in the pathophysiologyof breast cancer, and the sulfotransferase 1A (SULT1A) family has been found to be both downstream targetsof tamoxifen and a risk factor of breast cancer. We have used PCR-RFLP and direct sequencing methodsto determine SULT1A2 polymorphisms in 230 Taiwanese breast cancer patients. The results showed that thefrequencies of SULT1A2*1 and SULT1A2*2 occurring were 94.8% and 5.2%, respectively. No SULT1A2*3 allelewas found in these patients. In comparison with the frequency of healthy controls (96.0% and 4.0% forSULT1A2*1 and SULT1A2*2, respectively), the allelic frequencies of SULT1A2 polymorphisms in these patientswere not statistically significant (p=0.398). However, the SULT1A2*2 allele seems to influence the ageof onset among early-onset breast cancer patients (p=0.021, OR=2.74, 95%CI=1.13-6.65).
    關聯: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 10(5 )609 ~612
    顯示於類別:[台中附設醫院] 期刊論文

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