The estrogen-signaling pathway plays an important role in the pathophysiologyof breast cancer, and the sulfotransferase 1A (SULT1A) family has been found to be both downstream targetsof tamoxifen and a risk factor of breast cancer. We have used PCR-RFLP and direct sequencing methodsto determine SULT1A2 polymorphisms in 230 Taiwanese breast cancer patients. The results showed that thefrequencies of SULT1A2*1 and SULT1A2*2 occurring were 94.8% and 5.2%, respectively. No SULT1A2*3 allelewas found in these patients. In comparison with the frequency of healthy controls (96.0% and 4.0% forSULT1A2*1 and SULT1A2*2, respectively), the allelic frequencies of SULT1A2 polymorphisms in these patientswere not statistically significant (p=0.398). However, the SULT1A2*2 allele seems to influence the ageof onset among early-onset breast cancer patients (p=0.021, OR=2.74, 95%CI=1.13-6.65).
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INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 10(5 )609 ~612