TAP 2 gene Msp-I polymorphism might be associated with calcium oxalate stone disease

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Title:	TAP 2 gene Msp-I polymorphism might be associated with calcium oxalate stone disease
Authors:	(Huang SH);(Chen RH);萬磊(Lei Wan);蔡輔仁(Fuu-Jen Tsai);陳汶吉(Chen Wen-Chi)*
Contributors:	中醫學院中西醫結合研究所;中國附醫泌尿部
Keywords:	Stone disease;Single-nucleotide polymorphism;Transporter associated with antigen-processing gene Introduction: Inflammation might be one of the causes of stone disease. The function of the transporter associated with antigen-processing protein (TAP) is related to immune response and inflammation. Our aim was to investigate the relationship between stone disease and 5 polymorphic sites of the TAP gene (TAP1-1, 1-2, 2-1, 2-2, 2-3). Materials and Methods: We compared the frequencies of 5 polymorphisms in the TAP gene between 208 patients with recurrent calcium oxalate stone and 210 healthy controls. The polymorphism was detected by polymerase chain reaction-based restriction analysis. Results: Significant differences in the frequency of the polymorphism at the TAP2-2 site were detected between normal individuals and calcium stone disease patients (p < 0.0001). The distribution of the genotype AA homozygote was higher in stone patients (33.3%) than in the control group (16.3%). The odds ratio for the A allele compared with the G allele was 2.097 (95% CI 1.571-2.802). Conclusions: We conclude that the TAP2-2 MspI polymorphism might be associated with calcium stone disease.
Date:	2005-04
Issue Date:	2009-08-24 14:40:23 (UTC+8)
Relation:	UROLOGIA INTERNATIONALIS 75(3)264 ~268
Appears in Collections:	[Graduate Institute of Integrated Medicine] Journal articles

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