空氣污染情形以及阿茲海默症之世代追蹤研究

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Title:	空氣污染情形以及阿茲海默症之世代追蹤研究 Air Pollution and Alzheimer’s disease: A Population-Based Prospective Cohort Study in Taiwan
Authors:	翁詩瑋;Shih-Wei Weng
Contributors:	職業安全與衛生學系碩士班
Keywords:	空氣污染物;阿茲海默症;世代追蹤研究;Air pollution;cohort study
Date:	2014-08-05
Issue Date:	2014-10-02 09:46:09 (UTC+8)
Publisher:	中國醫藥大學
Abstract:	背景: 在目前的動物實驗研究中，已經發現了空氣污染的影響會造成阿茲海默症的產生，但在流行病學的研究卻是只有少數討論到有關空氣汙染以及阿茲海默症相關的研究。本研究主將要探討空氣汙染以及罹患阿茲海默症的相關性。方法: 本研究以世代追蹤法進行研究，利用2000-2010年台灣全民健康保險研究資料庫做為本研究之主要世代。而在空氣污染物暴露部份，則使用環保署空氣品質監測站公布之資料，結合地理資訊系統使用反距離平方加權法，採25公里內最靠近的三個監測站為基準，進行個案暴露量之推估。結果:依照文獻指出阿茲海默症共分成四類,結果以阿茲海默症為範例，利用科克斯比例風險模式進行分析，初步結果發現有1764名阿茲海默症患者在本次研究中，並發現暴露於二氧化氮下，每增加一個四分位距的二氧化氮汙染，其罹患阿茲海默症之風險將提高1.16倍( HR=1.16, 95% CI: 1.09,1.24)，以及二氧化硫之風險為1.08倍(HR=1.08, 95% CI: 1.05, 1.12). 結論:結論可證實環境空氣汙染的影響以及罹患阿茲海默症的機率是有相關性的。 Background: There is evidence that air pollution may increase the risk of Alzheimer’s disease in animals, but limited epidemiological studies concerning the role of ambient air pollution in the relation to Alzheimer’s disease. The aim of this study will assess the relation between ambient air pollution and the risk of Alzheimer’s disease. Methods: We conducted a population-based 10-year prospective cohort study in Taiwan. The outcome of interest was development of Alzheimer’s disease during the study period from 2000 through 2010. The air pollutant measurements from 72 EPA monitoring stations are integrated into yearly point data and interpolated to pollutant surfaces using inverse distance weighting (IDW) method since 1994. The exposure assessment was based on residential zip-code during the study period. The effect estimates were presented as hazard ratios per interquartile range (IQR) for the air pollutant. Results: Alzheimer’s disease have four groups, this proposal show you about one, Alzheimer's disease. A total of 1764 subjects developed Alzheimer’s disease during the study period. In the Cox proportional hazard model adjusting for confounders, the risk of Alzheimer’s disease was increased in relation to NO2 (adjusted HR=1.16, 95% CI: 1.09,1.24) and SO2 exposure (adjusted HR=1.08, 95% CI: 1.05, 1.12). Conclusion: The study provides evidence that exposure to ambient air pollutants such as NO2 and SO2 may increase the risk of Alzheimer’s disease.
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