案例報告：克多炎止痛藥引發的急性氣喘發作

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 公共衛生學院 > 公共衛生學系暨碩博班 > 博碩士論文 > Item 310903500/52846

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题名:	案例報告：克多炎止痛藥引發的急性氣喘發作 Ketorolac-induced Asthma with Acute Exacerbation: A Case Report
作者:	鄒雨寰;Yu-Huan Tsou
贡献者:	公共衛生學系碩士班
关键词:	氣喘;克多炎止痛藥;案例報告;Ketorolac;Asthma;Case Report
日期:	2014-07-21
上传时间:	2014-10-02 09:40:24 (UTC+8)
出版者:	中國醫藥大學
摘要:	氣喘為人體的一種呼吸道慢性發炎疾病，大部分的氣喘病人在平常可以擁有如一般人的生活品質，但當經歷誘發因子的誘導後就有可能會產生急性過敏症狀。這些又發因子包含內在因素(例：情緒壓力)、外在因素(例：塵?)，以及醫源性因素(例：醫療藥物)等。克多炎止痛藥(Ketorolac)是一種非類固醇類消炎鎮痛藥(NSAIDs)，目前被廣泛運用在急診的病人以及手術後病人的疼痛照護。然而，有些發生急性氣喘的案例被指出有可能與這類非類固醇類消炎鎮痛藥物藥理作用機轉有關。而此篇案例報告將會呈現一位患有氣喘的病人因為克多炎止痛藥物而引發的急性氣喘發作。根據之前的案例報告、相關文獻探討、藥物機轉認識，以及此次的案例經驗，我們認為克多炎止痛藥物有可能會誘發急性氣喘發作。因此，我們建議醫療照護人員對於過去患有氣喘疾患的病人，在施予克多炎止痛藥物時需要非常小心謹慎，同時對於病人的過去疾病病史應該要詳細詢問與瞭解。即便初步排除了危險因子而決定給予藥物，在施予藥物後也需要密切觀察病人有無任何不適的狀況。 Asthma may be described broadly as a chronic inflammatory disorder of the airways. Most patients could have stable asthma for weeks or months, and then suddenly develop an episode of acute asthma. As we know, different patients may react to various factors and several triggering agents, like house dust mite, emotional stress, and iatrogenic factor. Ketorolac is an analgesic that belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is frequently used in medicine for the patients who need pain control. However, the drug was suspected in previous study that it may induce adverse reaction after injection the drug. In this case report, we describe that a patient with the past history of asthma had asthmatic exacerbation after administering the Ketorolac, and then she experienced the life-threatening complication. According to previous reports and our case experience, we suggest that healthcare professionals should pay great attention to the patient with past history of asthma before prescribing Ketorolac. Detail history taking and closely monitoring after injecting the drug are required.
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