骨質疏鬆症好發於停經後的婦女，常造成脊椎體、 髖部與腕部骨折。
人類的骨骼約有百分之十持續的進行骨重塑作用，此一作用包括骨頭的生成與溶蝕兩種作用，骨質疏鬆症即是此兩種作用失去平衡所造成。而其中生成作用由成骨細胞所主導，本研究將探討中藥對於成骨細胞活性的影響。
本研究選定十二種常見補腎強筋骨中藥粗萃取物，並以 MC3T3-E1成骨細胞株來探討。實驗分成兩部分，第一部份評估十二種中藥粗萃取物對 MC3T3-E1成骨細胞株的影響。第二部分選定其中有效藥物肉蓯蓉並對其機轉做進一步的探討。
結果顯示，肉蓯蓉能夠促進 MC3T3-E1成骨細胞株的活性與加強礦化作用，根據本研究的結果，肉蓯蓉粗萃取物可為骨質疏鬆症的治療提供一個新的方向。
Osteoporosis frequently occurs in women after menopause, often caused fracture of vertebral body, hip and wrist. About ten percent of human bone role in the effect of bone remodeling includes both bone formation and dissolution. Osteoporosis took place by the unbalance of these two effects. Osteoblasts make bone formation and in this study we explore Chinese herbal medicine for the activity of osteoblast.
Our study used twelve selected common Bushen chinese herbal medicine crude extracts and MC3T3-E1 osteoblast cell line. Our research
divided into two parts. The first part was to evaluate the effect of the twelve Bushen chinese herbal medicine crude extracts on MC3T3-E1 osteoblast cell line. Then we selected one of the effective drugs C.
deserticola to make more advanced study. Our results revealed C. deserticola promote cell activity and mineralization in MC3T3-E1
osteoblast cell line. According to the results of this study, C. deserticola
extracts provide a new direction for the treatment of osteoporosis.
