根據衛生署國人十大死因排名統計，肝臟疾病一直榜上有名。其中，B型及C型肝炎病毒(Hepatitis B/C virus, HBV/HCV)感染易發展為慢性肝炎、肝硬化、甚至是肝癌。而臨床上對於這些患者的血液生化分析，僅止於一般肝功能檢測，較無整體氧化傷害或發炎指標之分析。故本研究欲探討B型及C型肝炎患者，其血液發炎及氧化傷害相關因子之變化，做為日後臨床診斷或治療的參考依據之一。
本研究共收案118位B型肝炎、110位C型肝炎門診病患；另招募26位健康民眾做為正常組。採集血液之後，分析並比較血液生化值(如天門冬胺酸轉胺?、丙胺酸轉胺?)、脂質代謝(如三酸甘油酯、膽固醇)、氧化傷害(如總抗氧化力、脂質過氧化物)、及發炎反應相關因子(如前列腺素E2、環氧化?-2)之活性或含量。
結果發現，相較於正常組，疾病組之脂質代謝、氧化傷害及發炎因子均顯著異常。其中B型肝炎患者氧化傷害較C肝患者嚴重，而C型肝炎患者發炎情形則是較B肝患者嚴重；此外，兩種肝炎患者都已檢測到纖維因子的產生。這些結果顯示此兩種病毒造成的感染，似乎有著不同疾病進程，但都會造成更嚴重之後果。最後藉此期許飲食營養能對治療慢性肝炎有所協助。
Hepatitis B and C virus (HBV / HCV) infection is the major cause to promote the progression of hepatitis, cirrhosis, and even hepatocellular carcinoma. The aim of present study was to investigate and compare the variation of factors associated with oxidative and inflammatory stress between HBV and HCV infected patients. One hundred and eighteen HBV, 110 HCV patients, and 26 normal controls were included. The following factors in blood from patients and controls were determined: alanine transaminase (ALT), aspartate transaminase (AST), triglycerides (TG), cholesterol, total antioxidant, lipid peroxides, prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2). Results showed that HBV patients had significantly higher oxidative damage (p<0.05); HCV patients had significantly greater inflammatory stress (p<0.05). Fibrotic factor could be detected in both groups. These findings revealed that pathological processes in HBV or HCV patients might be different, and both resulted in more serious consequences. In order to attenuate these healthy risks, the intervention of dietary management might be helpful for chronic hepatitis patients.
