良性攝護腺肥大 (BPH)是老年男性常見的疾病，許多代謝症候群的危險因子如胰島素阻抗、高血壓及肥胖都與良性攝護腺肥大有關。已知攝護腺細胞的生長會受性荷爾蒙包括雌激素、睪固酮、二氫睪固酮 (DHT)和5α-還原?; (5α- reductase)等調控。一直以來，運動已被認為有益於代謝症候群，能負調控良性攝護腺肥大的生長。在本實驗中，我們運用合併良性攝護腺肥大及糖尿病的動物模式來探討運動對攝護腺肥大的效果。實驗結果顯示運動不僅能改善糖尿病組的攝護腺相對重量，還能有效調控其睪固酮含量，並且也改善了糖尿病及良性攝護腺肥大合併糖尿病組的二氫睪固酮含量。然而，只有BPH+ DM組的IL-6在經過運動之後恢復正常值，運動似乎在降低攝護腺發炎的現象並無太大效用。總結本實驗結果，發現運動能藉由調控荷爾蒙而改善糖尿病患者的攝護腺異常增生。
Benign prostatic hyperplasia (BPH) is one of the most common diseases among aging men. Many risk factors of the metabolic syndrome (MS) such as insulin resistance, hypertension and obesity are linked to BPH. The growth of prostatic cells is regulated by sex hormones, including estrogen, testosterone (T), dihydrotestosterone (DHT) and 5α-reductase. Exercise has shown to be beneficial to MS. The development of BPH is inversely related to exercise. In this present study, the combined BPH-diabetes (DM) rat model was used to investigate the effect of exercise on BPH. Results showed that exercise alleviated the ratio of prostate to body weight in DM group and also regulates it’s testosterone level, exercise also altered DHT level in both DM and BPH+DM groups. Besides, exercise only showed its effect on reversing interleukin-6 (IL-6) in BPH+DM group to normal. Exercise was likely less benefit on ameliorating inflammation. As the conclusion, exercise was beneficial by hormone regulation on abnormal growth of prostates in DM group.
