The profile of cardiac cytochrome c oxidase (COX) expression in an accelerated cardiac-hypertrophy model

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Title:	The profile of cardiac cytochrome c oxidase (COX) expression in an accelerated cardiac-hypertrophy model
Authors:	郭薇雯(Wei-Wen Kuo);(Chu CY);吳介信(Chieh-Hsi Wu);(Lin JA);(Liu JY);(Ying TH);李信達(Shin-Da Lee);(Hsieh YH);(Hsu HH);黃志揚
Contributors:	醫學院生物科技學系
Keywords:	cytochrome c oxidase (COX);complete coarctation;cardiac hypertrophy;genetically hypertensive rats
Date:	2005-11
Issue Date:	2009-08-21 11:03:43 (UTC+8)
Abstract:	The contribution of the mitochondrial components, the main source of energy for the cardiac hypertrophic growth induced by pressure overload, is not well understood. In the present study, complete coarctation of abdominal aorta was used to induce the rapid development of cardiac hypertrophy in rats. One to two days after surgery, we observed significantly higher blood pressure and cardiac hypertrophy, which remained constantly high afterwards. We found an early increased level of cytochrome c oxidase (COX) mRNA determined by in-situ hybridization and dot blotting assays in the hypertrophied hearts, and a drop to the baseline 20 days after surgery. Similarly, mitochondrial COX protein level and enzyme activity increased and, however, dropped even lower than baseline 20 days following surgery. In addition, in natural hypertension-induced hypertrophic hearts in genetically hypertensive rats, the COX protein was significantly lower than in normotensive rats. Taken together, the lower efficiency of mitochondrial activity in the enlarged hearts of long-term complete coarcted rats or genetically hypertensive rats could be, at least partially, the cause of hypertensive cardiac disease. Additionally, the rapid complete coarctation-induced cardiac hypertrophy was accompanied by a disproportionate COX activity increase, which was suggested to maintain the cardiac energy-producing capacity in overloaded hearts.
Relation:	JOURNAL OF BIOMEDICAL SCIENCE12(4):601~610
Appears in Collections:	[Department of Biological Science and Technology] Journal articles

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