Association of L-myc polymorphism with lung cancer susceptibility and prognosis in relation to age-selected controls and stratified cases.

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Title:	Association of L-myc polymorphism with lung cancer susceptibility and prognosis in relation to age-selected controls and stratified cases.
Authors:	施純明(Chuen-Ming Shih);(Kuo YY);(Wang YC);(Jian SL);(Hsu YT);(Wu HY);(Guo MW);王憶卿(Wang YC)
Contributors:	健康照護學院二年制呼吸治療學系學士班在職專班;中國附醫內科部胸腔科
Keywords:	Lung cancer;L-myc polymorphism;Cancer susceptibility;Prognosis
Date:	2002-05
Issue Date:	2009-08-20 22:13:34 (UTC+8)
Abstract:	The association of L-myc polymorphism with cancer susceptibility and prognosis has produced conflicting results. This may have been due to racial/ethnic differences and methodological variations in the studies, such as, control selection and case stratification. Therefore, we investigated the genotype distribution of the L-myc polymorphism in 169 lung cancer patients and 169 non-cancer controls, and analyzed the association of this polymorphism with cancer susceptibility and prognosis in relation to age-specific controls as well as stratified cases. The genotype frequencies in the Taiwanese non-cancer controls were 0.56 (L) and 0.44 (S). Chi-square (chi(2)) analysis indicated a significant difference in the Taiwanese genotype distribution of L-myc compared with that of African-Americans (P=0.001). Logistic regression analysis of cases/controls, adjusted for both age and sex, indicated that an increased frequency of the LL genotype was observed in early-staged patients compared with the non-cancer controls (OR=0.43, 95% CI, 0.20-0.94, P=0.03). In addition, the frequency of the LL genotype was significantly higher in stages I+II patients (47.4%) than in stages III+IV patients (28.4%) (P=0.05). Furthermore, the S allele frequency was significantly increased in stages III+IV patients (P=0.005). As both L-myc and p53 polymorphisms were analyzed for their prognostic value, the patients with an S allele of the L-myc gene and a Pro/Pro variant genotype of the p53 gene had significantly poorer prognoses compared with other patients (P=0.004, by the log rank test). These data suggest that the S allele of the L-myc polymorphism may be associated with lung cancer progression.
Relation:	LUNG CANCER36(2):125~132
Appears in Collections:	[Department of Respiratory Therapy] Journal articles

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