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    題名: 市售40種中藥材化學規格測定及金銀花、忍冬藤及木蝴蝶之主成分含量測定;Studies on the Chemical Specification of Forty Chinese Drugs and Quantitative Analysis of Major Ingredients of Chin-Yin Hua ,Ren-Dong Teng and Mu-Hu Die
    作者: 王靜瑩;Ching-Ying Wang
    貢獻者: 中國醫藥大學:中國藥學研究所碩士班
    關鍵詞: 中藥材;乾燥減重;總灰分;酸不溶性灰分;稀醇抽提物;水抽提物;HPLC;Chinese herbs;loss on drying;total ash;acid-insoluble ash;diluted ethanol-soluble extractive;water-soluble extractive
    日期: 2007-06-27
    上傳時間: 2009-08-11 10:25:28 (UTC+8)
    摘要: 行政院衛生署中醫藥委員會於93年3月9日公告國內第一部中華中藥典(已改名台灣傳統藥典),第一版台灣傳統藥典收載中藥品項僅200種,距離大陸中華人民共和國藥典及日本藥局方收載之品項仍有相當大之距離,須在再版中增補品項,因此未來新收載品項之化學規格的建立,實為極重要之課題。
    本計畫針對大陸藥典一部收載但台灣傳統藥典中未收載之中藥品項,去除台灣地區較少或未見使用之品項,選擇川木香等40種藥材,每種藥材在全省各地收集20種檢品,進行乾燥減重、總灰分、酸不溶性灰分、稀醇抽提物及水抽提物等項目試驗。另外並選擇金銀花、忍冬藤、木蝴蝶等三種中藥材,以HPLC進行其指標成分chlorogenic acid及baicalin之定量分析。
    除了本實驗室進行之實驗外,亦收集各國藥典上述藥材之各項理化試驗之數據,並與藥檢局及國內主要中藥廠代表舉行座談,討論相關數據,使相關化學規格之數據建議更為可行。

    The Committee of Chinese Medicine and Pharmacy, Department of Health completed the first version of Chinese Herbal Pharmacopeia in 2004. The first version included only 200 Chinese crude drugs species. However the items included were too less comparing to the numbers of items included either in the Pharmacopeia, PRC, 2005 or Japanese Pharmacopeia, 14th Edition, 1996. More items should be included in the upcoming revised version. Then chemical specification of those new items needed to be established.
    We selected 40 commonly used items which were recorded in PRC Pharmacopeia but not in Taiwanese Herbal Pharmacopeia. Twenty specimen of each 40 herbs were purchased around the island. Five tests including loss on drying, total ash, acid-insoluble ash, diluted ethanol-soluble extract, water-soluble extract of 20 samples of each herb were analyzed. Additionally, Lonicera Japonica Flos, Lonicerae Japonicae Calulis and Oroxyli Semen were selected for HPLC analysis for the contents of their marker constituents, chlorogenic acid or baicalin.
    Besides referring to other related pharmacopeias, we also consulted staffs from Bureau of Food and Drug Analysis and QC staffs from major GMP Pharmaceutical factories to ensure the feasibility of the specification. The results will be provided as major references for revising the new edition of the Taiwanese Herbal Pharmacopeia.
    顯示於類別:[中國藥學研究所(已停用)] 博碩士論文

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