雄性激素接受器於子宮內膜癌幹細胞及癌細胞的影響

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题名:	雄性激素接受器於子宮內膜癌幹細胞及癌細胞的影響 http://grbsearch.stpi.narl.org.tw/GRB/result.jsp?id=2363062&plan_no=NSC100-2314-B039-041&plan_year=100&projkey=PC10009-0095&target=plan&highStr=%E9%9B%84%E6%80%A7%E6%BF%80%E7%B4%A0%E6%8E%A5%E5%8F%97%E5%99%A8%E6%96%BC%E5%AD%90%E5%AE%AE%E5%85%A7%E8%86%9C%E7%99%8C%E5%B9%B9%E7%B4%B0%E8%83%9E%E5%8F%8A%E7%99%8C%E7%B4%B0%E8%83%9E%E7%9A%84%E5%BD%B1%E9%9F%BF&check=0&pnchDesc=%E9%9B%84%E6%80%A7%E6%BF%80%E7%B4%A0%E6%8E%A5%E5%8F%97%E5%99%A8%E6%96%BC%E5%AD%90%E5%AE%AE%E5%85%A7%E8%86%9C%E7%99%8C%E5%B9%B9%E7%B4%B0%E8%83%9E%E5%8F%8A%E7%99%8C%E7%B4%B0%E8%83%9E%E7%9A%84%E5%BD%B1%E9%9F%BF
作者:	陳璐敏(Lu-Min Chen);洪耀欽(Yao-Ching Hung);馬文隆(Wen-Lung Ma);張穎宜(Yin-Yi Chang)
贡献者:	中國附醫婦產部
关键词:	男性激素受體;子宮內膜癌;癌幹細胞;androgen receptor;endometrial cancer;cancer stem cells
日期:	2012-07-31
上传时间:	2013-01-25 13:44:43 (UTC+8)
摘要:	子宮內膜癌是婦科癌症中常見的疾病，有研究發現到在人類內膜中有極少的上皮幹細胞。這些幹細胞很可能是癌症幹細胞的來源，而癌症幹細胞可以啟動和維持子宮內膜癌症。癌症幹細胞的定義是一群擁有自我重生、分化及?生能力的細胞。癌症幹細胞在抗藥性和癌症生成上扮演了很重要的角色。子宮內膜癌幹細胞可能位於一般癌症細胞中，它們有些特別的細胞表面標記。本實驗目標為把這些細胞分離出來後，研究它們在人類子宮內膜癌症中的角色。另外雄性激素接受器亦在子宮內膜癌中扮演重要角色，研究證據顯示子宮內膜有雄性激素接受器的表現和雄性激素接受器在正常內膜或子宮內膜癌細胞?生上都有其作用。但雄性激素接受器在子宮內膜癌症生成的角色仍未完全了解。此研究將進一步分析雄性激素接受器在子宮內膜癌幹細胞上是否有其角色及其作用。本研究目標期望能助於開啟子宮內膜癌新的治療方法和不同的思維。 Endometrial cancer (EMC) is the one of the most common gynaecological malignancy affecting women. Given that a rare population of epithelial stem cells has been identified in human endometrium, it is possible that these cells or their progency may be the source of the putative cancer stem cells that may initiate and maintain endometrial cancer. Cancer stem cells are defined as a subset of tumor cells with the capacity of self-renewal, proliferation and differentiation ability. Cancer stem cells also have an important role in tumourigenesis and drug resistance in solid tumor. The cancer stem cell hypothesis provides an attractive cellular mechanism to account for the therapeutic refractoriness and dormant behavior. Endometrial cancer stem cells may be located within the tumour cell population which expressing variety of markers on their cell surface. We will isolate and characterized the endometrial cancer stem cells and their role in the development of human endometrial cancer. Furthermore androgens also act on endometrial cancer by interacting with the androgen receptor (AR). Evidence has suggested that endometrial contains androgen receptors (ARs), and androgens/ARs are involved in both normal and cancerous endometrial cell proliferation. However, the specific roles of androgens and the AR in the uterus and in endometrial carcinogenesis are not fully understood. We will further evaluate the AR effect on the endometrial cancer stem cell tumourigenesis and this will opens the way for the development of new treatment modalities that target the cancer stem cell and androgen receptor.
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