中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/46139
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    Title: 染料製造業工人職業暴露與癌症發生之關聯性,1979-2007
    Occupational Exposure of Dye Manufacturing Industry Workers and their Association with Cancers in 1979-2007
    Authors: 呂明益;Lu, Ming-Yi
    Contributors: 生物統計研究所碩士班
    Keywords: 聯苯胺;癌症;標準化發生率;benzidine;cancer;standardized incidence ratio
    Date: 2012-07-25
    Issue Date: 2012-08-31 16:30:42 (UTC+8)
    Publisher: 中國醫藥大學
    Abstract: 目的:
    台灣地區染料製造業已有50年的歷史,直到西元1992年才全面禁止聯苯胺進口、製造以及使用,為得知染料工人在長期職業暴露之健康狀況是否受到影響,以及聯苯胺禁用前後染料製造業工人的健康狀態。本研究藉由長時間的流行病學方法進行追蹤探討染料製造業工人職業暴露與癌症發生之關聯性。

    研究方法與結果:
    本研究採回溯型世代研究設計,從勞工安全衛生研究所提供的世代名冊中,選擇染料製造業工人做為研究對象並串聯死亡登記檔及癌症登記檔,並排除了14 歲以下的染料工人,從1979 年1 月追蹤至2007 年12月。另外,分別依照染料工人與職安人員以及染料工人與全國一般族群的性別和年齡分別進行1:1 和1:2 的配對。結果發現,1979 年到2007年間共包含了13,054 名染料工人,而配對之後的染料工人與職安人員共有20,822 名。多變量Cox proportional hazard model 分析結果顯示只有年齡與染料工人罹癌風險有統計上的顯著相關,56 歲以上的染料工人罹癌風險高於40 歲以上的染料工人(HR=1.88 (1.38-2.56))。
    染料工人與職安人員配對的多變量條件式邏輯斯迴歸分析顯示,工作年資與染料工人罹癌風險有統計上的顯著相關,工作年資越長罹癌風險反而較低(OR=0.93 (0.90-0.96));而與一般族群配對結果顯示染料工人罹癌風險顯著高於職業安全衛生人員,全國一般族群相對於職安人員的罹癌風險又高於染料工人(OR 分別為1.79 (1.46-2.20)、2.06 (1.72-2.47))。

    結論:
    本研究發現在 1979 年至2007 年間女性染料製造業工人的呼吸系統及胸腔內器官方面的癌症之標準化發生率顯著高於國人。染料工人的年齡與染料工人罹癌風險有關。與過去部分研究結果不同,工作年資、暴露程度、工廠類別、聯苯胺禁用前後與染料工人罹癌風險沒有統計上的顯著相關。在本研究中也觀察到了染料工人罹癌風險顯著高於職業安全衛生人員,而全國一般族群相對於職安人員的罹癌風險又高於染料工人,推論染料工人的健康工人效應以及工作年資分布差異大的影響造成低估罹癌的風險,可能影響本研究的結果。
    Aim:
    Dye manufacturing industry have existed for 50 years in Taiwan. The ban on import, manufacturing, and use of benzidine did not happen until 1992. In order to understand if health status of dye workers has been affected by their long term occupational exposure to the chemical, as well as the impact of policy ban, this study aims to study a cohort of dye manufacturing industry workers. We hope to explore the association between their benzidine exposure to cancer incidence.
    Methods and Results:
    This study adopts a retrospective cohort study design, whose roster was provided by the Institute of Labor Safety and Health. Basic information of dye manufacturing workers equal to or above the age of 14 years was merged with death registration file and cancer registry files from January 1979 to December 2007. Dye workers were matched by age and sex with occupational safety and health personnel, as well as the general population at 1:1 and 1:2 ratios, respectively. A total of 13,054 dye workers were selected from 1979 and 2007, and 20,822 occupational safety and health personnel were chosen following matching. Results of multivariate Cox proportional hazard model analysis showed that only age had significant association with cancer risk of dye workers, and dye workers aged more than 56-year-old had higher cancer risk than dye workers of age over 40 (HR = 1.88 (1.38-2.56)).
    Conditional logistic regression analysis showed that working period had a significant association with dye workers cancer incidence, longer working period had lower cancer risk (OR = 0.93 (0.90-0.96)). Results of matching with general population showed dye workers’ cancer risk was significantly higher than the occupational safety and health personnel, the general population relative to the occupational safety and health personnel had higher cancer risk than the dye workers (OR were 1.79 (1.46-2.20), 2.06(1.72-2.47)).
    Conclusion:
    This study found that the dye manufacturing workers of women respiratory and intrathoracic organs cancer standardized incidence ratio were significantly higher than general population in 1979-2007. Age had association with cancer occur risk in dye workers. This finding is different with past results where working period, exposure level, factory category, before and after benzidine ban were not statistically significant associated with dye worker’s cancer risk. In the present study, we also observed the dye workers’s cancer risk was significantly higher than the occupational safety and health personnel, general population relative to occupational safety and cancer risk higher than the dye workers, the healthy worker effect and distribution of working period of the large differences in dye workers impact of underestimated the risk of cancer, may affect the results of this study.
    Appears in Collections:[Graduate Institute of Biostatistics] Theses & dissertations

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