Tai-Yi Kao Plaster(TYK Plaster) is a traditional Chinese medicine, formulation containing Cinnamon、Dahurian angelica root、Angelica root、Ginseng、Red peony root、Rehmannia root、Myrrh and Sesame oil etc. , It was widely used in the treatment of muscles and bones ache、such as injuries from falls、contusions and strains. In this study, several formulations of TYKP Plaster were evaluated. The first, Extract with different solvents . Result show, extract with 50% ethanol result as good, secondly it is water, the worst is the sesame oil extract the result.
The different extracts of TYK cooperate with Cabopol 940、Acacia and Resin to manufacture the transdermal delivery system. Then explore the release of Paeoniflorin by dissolution test. A simple and sensitive HPLC method was developed for simultaneous determination of the active constituents of TYK Plaster, Paeoniflorin. The 5ODS column and the mobile phase consisted of Methanol and Water (40:60) was used. Flow rate was 0.8 ml/min. The monitoring wavelength was 230nm, respectively.
Internal standard was Methylparaben.
Every prescription makes up a release amount with E1 and E2 best, S3 is unable to measure for being worst. By comparing the physical properties and dissolution data, the best formulation of rapid released TYK Plaster was E2. It was composed of extracts with 50% ethanol and polymer
with Acacia was chosed.
