| 摘要: | 隨著醫學、生物科技、領域的快速發展，人類的平均壽命逐年增加，但心血管疾病而 導致的死亡率依然高居國內死亡原因的第三位，除慢性疾病如：高血壓、糖尿病、腎 臟病等會造成心血管疾病的發生，目前高齡族群和高壓專業人士亦為患有心血管疾病 的高危險族群，中風和心肌梗塞的猝死事件常發生在週遭的人身上，因此本子計畫主 要發展「簡易型心血管功能檢測系統」，本計畫是以非侵入式方法，利用壓振式理論， 建立肱動脈的動態血管順應性模型，即為「動脈的動態壓力─體積曲線」，並以 Windkessel 模型估測出心輸出量和動脈血管的阻尼數，此可有效的評估出動脈硬化和 阻塞的程度，並具有穩健性的測量動脈血壓和心率不整的偵測。由於簡易型非侵入式 的心血管功能測量數據的穩定性、準確性就相對重要，包含有血壓值、動脈體積變化 量、和血流量。此外，所測量出的動脈硬化數據的量化標準也需定義，本計畫將根據 手臂組織特性，來修正壓振式血壓測量參數，並透過影像處理方法，尋找出動脈管內 壁的動態邊界，準確算出動脈體積變化量，近而算出血流量的變化。配合動脈內皮細 胞功能的檢測(PAT-2000)，比對本計畫的動脈順應性值，定義出量化標準。此測量裝置 相同於目前居家使用的血壓計，具有極佳的操作方便性，即使是居家老人亦可使用， 透過無線傳輸的功能，能將資料傳遞至中央控制端，而隨時監測患者的心血管狀態。
Because the medicine, biological technique have been developed quickly, humans’ life also have increased. But, the mortality of cardiovascular diseases is still at the third in our country. Besides, the chronic diseases, like as hypertension, diabetes, or nephropathy, will bring about the cardiovascular diseases. Elders and professors how have the high stress also are the high danger group. The people who happened the apoplexy or myocardium infarction and died always was our friends or families. Therefore, this plane is to develop “A simple cardiovascular function measurement system”. In this study, a noninvasive method which uses the oscillometry to construct the compliance of the brachial artery, that is the arterial dynamic pressure?volume curve. Windkessel model is used to approach the cardio output and vascular resistor. It could estimate the degree of arterial stiffness and infarction, increase the robust of the blood pressure measurement, and alarm the arrhythmia states. Because the measurement system of the simple type has to own the stability and accuracy for the measuring values, the calibrations for the blood pressure, the change of the arterial volume, and blood flow are also an important topic. Moreover, the arterial compliance in our plane needs to be scaled. In our study, the tissue characteristic of the arm will be used to adjust the parameter of the oscillometry. The margin of the arterial inside wall will be detected by the image process technology which could be used to calculate the change of the arterial volume and blood flow. The endothelioid function using PAT-2000 to measure will be utilized to define the normal or abnormal range of the arterial compliance. This measurement system likening as the sphygmomanometer of home care has a easy operation and could transfer the data to central monitor for monitoring the cardiovascular condition. |
