停經對於心臟FAS, MITOCHONDRIAL, CASPASE-INDEPENDENT 凋亡的影響和治療的探討:1. 山藥補充 2. DIASGENIN補充 3.DIASGENIN補充配合運動療效

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 健康照護學院 > 物理治療學系暨復健科學碩士班 > 研究計畫 > Item 310903500/44192

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题名:	停經對於心臟FAS, MITOCHONDRIAL, CASPASE-INDEPENDENT 凋亡的影響和治療的探討:1. 山藥補充 2. DIASGENIN補充 3.DIASGENIN補充配合運動療效
作者:	李信達(Shin-Da Lee)
贡献者:	健康照護學院物理治療學系;中國附醫醫學研究部
日期:	2009-07-31
上传时间:	2012-06-13 09:23:03 (UTC+8)
摘要:	在更年期以後的心臟病apoptosis山藥的保護作用的信息有限。這項研究的目的將評估山藥的作用對雙邊卵巢切除術導致了心臟病apoptotic途徑。在6-7個月的四十八隻母Wistar鼠年齡被分了成sham-operated小組(n=12)，雙邊卵巢切處的小組(OVX， n=12) 2個月和與每日250 ml/kg或者750 ml/kg的山藥spp.減少了OVX導致的TNF-alpha，FADD，caspase 8和caspase 3。山藥spp.減少了OVX導致的傷害， Bax， Bax對Bcl2比率、caspase 9和caspase 3 (線粒體路)。山藥spp.壓制卵巢切除術導致了在鼠模型的心臟病。研究結果山藥也許為潛在防止心臟病apoptosis提供其中一種治療方法。 Very limited information regarding the protective effects of dioscorea on cardiac apoptosis after post-menopause or bilateral oophorectomy in women was available. The purpose of this study was to evaluate the effects of dioscorea on bilateral ovariectomies induced cardiac Fas-dependent and mitochondria-dependent apoptotic pathways. Forty-eight female Wistar rats at 6-7 months of age were divided into sham-operated group (Sham, n=12), bilateral ovariectomized group (OVX, n=12) for 2 months, and OVX groups with 250 ml/kg, or 750 ml/kg dioscorea spp. daily (Ovx 250 n=12; Ovx 750, n=12) in the 2nd month. The excised hearts were measured by positive TUNEL assays, Western Blotting and RT-PCR. Dioscorea spp. decreased OVX-induced cardiac TUNEL-positive apoptotic cells. Dioscorea spp. decreased OVX-induced TNF-alpha, Fas ligand, Fas death receptors, Fas-associated death domain (FADD), activated caspase 8, and activated caspase 3 (Fas pathways). Dioscorea spp. decreased OVX-induced Bad, Bax, Bax-to-Bcl2 ratio, activated caspase 9, and activated caspase 3 (mitochondria pathway). Dioscorea spp. suppressed ovariectomy-induced cardiac Fas-dependent and mitochondria-dependent apoptotic pathways in rat models. The findings may provide one of possible phyto-therapeutic approaches of dioscorea for potentially preventing cardiac apoptosis after bilateral ovariectomy.
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