Imipramine, clomipramine, and trimipramine have a long-acting spinal anesthetic effect

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 健康照護學院 > 物理治療學系(停用) > 期刊論文 > Item 310903500/4418

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题名:	Imipramine, clomipramine, and trimipramine have a long-acting spinal anesthetic effect
作者:	陳郁文(Yu-Wen Chen);(Shieh JP);(Chen JY);(Chu CC);(Tzeng JI)*;(Wang JJ)
贡献者:	健康照護學院物理治療學系
关键词:	脊椎腔內;疼痛;脊髓;三環抗憂鬱藥物;Imipramine;Intrathecal;Pain;Spinal;Tri-cyclic antidepressant
日期:	2006-01
上传时间:	2009-08-20 20:53:42 (UTC+8)
摘要:	Objective: Recently, imipramine, a tri-cyclic antidepressant, was found to be effective in the treatment of neuropathic pain ofmultiple origins. Also, it was suggested to have a local anesthetic effect. However, its action on spinal function was not fullyunderstood. The aim of this study was to evaluate the spinal anesthetic effect of imipramine. Two commonly used local anesthetics,bupivacaine and lidocaine, were used as controls. Two other tri-cyclic antidepressants, clomipramine and trimipramine, which areanalogues of imipramine, were also studied. Materials and Methods: The potencies of the drugs and durations of spinal anestheticeffects on motor function, proprioception, and nociception were evaluated in male Sprague-Dawley rats. Results: We found that allof the drugs tested produced dose-related spinal blockades of motor function, proprioception, and nociception. The spinal blockadesof imipramine, clomipramine and trimipramine were more potent than that of lidocaine (p<0.05 for each comparison). The durationsof their actions were similar to that of the long-acting local anesthetic bupivacaine and longer than that of lidocaine (p<0.05 foreach comparison). Conclusion: Intrathecal imipramine, clomipramine, and trimipramine produce dose-related spinal anestheticeffects which are more potent and longer than that of lidocaine.
關聯:	慈濟醫學雜誌18(1):9~13
显示于类别:	[物理治療學系(停用)] 期刊論文

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