The Effects of Misclassification in Studies of Gene-Environment Interactions

CMUR > College of Health Care > Department of Dental Hygiene > Journal articles > Item 310903500/4397

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/4397

Title:	The Effects of Misclassification in Studies of Gene-Environment Interactions
Authors:	鄭光甫(Kuang-Fu Cheng);(Lin, W. J.)
Contributors:	健康照護學院口腔衛生學系;中國附醫院長室
Keywords:	Gene-environment interaction;Likelihood ratio test;Misclassification;Robustness
Date:	2009
Issue Date:	2009-08-20 20:43:33 (UTC+8)
Abstract:	Differential Misclassification of genotype may cause usual tests producing spurious gene-disease associations or unable to detect important associations. To control for the resulting bias, many model-based approaches have been proposed using validation data. However, the effects of joint misclassification of genotype and environmental exposure in studies of gene-environment interaction are still not clear. In this paper, we focus on quantifying the effects of misclassification in case-control and case-only studies of interaction without specifying any model for misclassification probabilities. By using the derived results, we are able to identify important conditions, under which the presence of misclassification does not introduce bias in case-control or case-only studies. We have conducted a simulation study, using parameter values from real examples, to confirm our theoretical findings. The simulation results show that under the identified conditions, many regular tests for the hypothesis of no interaction maintain correct type I error rates in the presence of differential misclassification. However, their powers may be decreased as misclassification error rates increase.
Relation:	HUMAN HEREDITY 67(2):77~87
Appears in Collections:	[Department of Dental Hygiene] Journal articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	346	View/Open

Loading...