Secondary Metabolites from the Roots of Neolitsea daibuensis and Their Anti-inflammatory Activity

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Title:	Secondary Metabolites from the Roots of Neolitsea daibuensis and Their Anti-inflammatory Activity
Authors:	(Su-Ling Wong);(Hsun-Shuo Chang);汪貴珍(Guei-Jane Wang);(Michael Y. Chiang);(Hung-Yi Huang);(Chu-Huang Chen);(Shiow-Chwen Tsai);(Chu-Hung Lin);(Ih-Sheng Chen)*
Contributors:	中國附醫L5研究中心
Keywords:	Secondary Metabolites
Date:	2011-12
Issue Date:	2012-04-26 16:00:55 (UTC+8)
Abstract:	Bioassay-guided fractionation of the roots of Neolitsea daibuensis afforded three new β-carboline alkaloids, daibucarbolines A–C (1–3), three new sesquiterpenoids, daibulactones A and B (4 and 5) and daibuoxide (6), and 20 known compounds. The structures of 1–6 were determined by spectroscopic analysis and single-crystal X-ray diffraction. Daibucarboline A (1), isolinderalactone (7), 7-O-methylnaringenin (8), and prunetin (9) exhibited moderate iNOS inhibitory activity, with IC50 values of 18.41, 0.30, 19.55, and 10.50 μM, respectively.
Relation:	JOURNAL OF NATURAL PRODUCTS 74(12):2489-2496
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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