Antidiabetes Drugs Correlate With Decreased Risk of Lung Cancer: A Population-Based Observation in Taiwan

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Title:	Antidiabetes Drugs Correlate With Decreased Risk of Lung Cancer: A Population-Based Observation in Taiwan
Authors:	賴世偉(Shih-Wei Lai);廖光福(Kuan-Fu Liao);陳培君(Pei-Chun Chen);蔡邦耀(Pang-Yao Tsai);謝顯堂(Dennis P H Hsieh)*;陳清助(Ching-Chu Chen)
Contributors:	公共衛生學院健康風險管理學系;中國附醫院長室
Keywords:	Diabetes mellitus;Insulin;Lung cancer;Metformin;Thiazolidinedione
Date:	2012-03
Issue Date:	2012-04-19 15:15:26 (UTC+8)
Abstract:	Background The risk of some forms of cancer has been found to be higher in patients with diabetes mellitus (DM) than in the general population. The aim of this study was to examine, with sufficient statistical power, the association between DM and lung cancer and the impact of antidiabetesdrugs on lung cancer risk in Taiwan. Materials and Methods From a randomly selected data set of 1 million National Health Insurance (NHI) claims in Taiwan from 2000-2005, 19,624 cases (patients ≥ 20 years of age) of newly diagnosed DM were identified. From the same data set, 78,496 enrollees with no record of DM were selected as controls and were matched in sex and age to the first group. The incidence of newly diagnosed lung cancer was compared between patients with DM and controls for a period of 9 years (2000-2008). Results The multivariate Cox model analysis showed a slightly increased hazard ratio (HR) of 1.05 of lung cancer in patients with DM, but the association was not statistically significant. However the use of antidiabetesdrugs, such as metformin, thiazolidinediones, or alpha-glucosidase inhibitors, correlates with adecreasedlung cancer risk of 39%-45%. A significant association was found between lung cancer risk and male sex (HR, 2.23), pulmonary tuberculosis (HR, 1.60), chronic obstructive pulmonary disease (HR, 1.21), and age (HR, 1.07). Conclusion Patients with DM are not at increased risk for the development of lung cancer, but the use of antidiabetesdrugs would considerably decrease the risk. In this cohort, male sex, age, pulmonary tuberculosis, and chronic obstructive pulmonary disease were all associated with an increased risk of lung cancer, consistent with findings in the literature and indicative of the validity of our study.
Relation:	Clinical Lung Cancer 13(2):143-148
Appears in Collections:	[Department of Health Risk Management] Journal articles

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