中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/43869
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    题名: A polymorphic -844T/C in FasL promoter predicts survival and relapse in non-small cell lung cancer.
    作者: (Wen-Wei Sung);Yao-Chen Wan;(Ya-Wen Cheng);(Ming-Ching Lee);(Kun-Tu Yeh);(Lee Wang);(John Wang);陳志毅(Chih-Yi Chen);(Huei Lee)*
    贡献者: 健康照護學院二年制呼吸治療學系;中國附醫癌症中心
    关键词: FasL -844T/C;NSCLC
    日期: 2011-09
    上传时间: 2012-04-19 11:25:18 (UTC+8)
    摘要: Purpose:Fas ligand (FasL) −844T/C polymorphism (rs763110) has a demonstrated association with lung cancer risk. FasL −844CC with higher FasL expression has been suggested to contribute to tumor progression via immune escape. However, the impact of FasL −844T/C polymorphism on the clinical outcome of non–small cell lung cancer (NSCLC) remains to be identified.

    Experimental Design: A total of 385 adjacent normal lung tissues from patients with NSCLC were collected to determine FasL −844T/C polymorphism by PCR-based restriction fragment length polymorphism. FasL mRNA and protein expression in lung tumors were evaluated by real-time PCR and immunohistochemistry. The prognostic value of FasL −844T/C polymorphism on survival and relapse was determined by Kaplan–Meier analysis and Cox proportional hazards models.

    Results: The FasL −844CC genotype had higher prevalence in those with advanced tumors than in those with early tumors (P = 0.008). In addition, patients with the FasL −844CC genotype were more prone to tumor relapse than those with the FasL −844TT+TC genotype (62.1% vs. 37.9%, P = 0.001). Multivariate Cox regression analysis showed that patients with the FasL −844CC genotype had poorer survival in terms of overall survival (OS) and relapse-free survival (RFS) than those with the FasL −844TT+TC genotype (24.1 vs. 42.8 months for OS, HR = 1.455, P = 0.004; 15.4 vs. 31.4 months for RFS, HR = 1.710, P < 0.001).

    Conclusions:FasL −844T/C polymorphism may predict survival and relapse in NSCLC. We suggest that FasL may be a molecular target for immunotherapeutic interventions to improve the clinical outcome of patients with NSCLC. This finding should be validated by another investigative group.
    關聯: CLINICAL CANCER RESEARCH 17(18):5991-5999
    显示于类别:[二年制呼吸治療學系] 期刊論文

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