The association between polymorphisms of B7 molecules (CD80 and CD86) and Graves' Ophthalmopathy in a Taiwan population

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Title:	The association between polymorphisms of B7 molecules (CD80 and CD86) and Graves' Ophthalmopathy in a Taiwan population
Authors:	廖文伶(WEN-LING LIAO);陳榮興(Rong-Hsing Chen);林慧茹(Hui-Ju Lin);呂郁蕙(Yu-Huei Liu);陳汶吉(Chen, Wen-Chi);蔡育勳(Yuhsin Tsai);萬磊(Lei Wan);蔡輔仁(Fuu-Jen Tsai)
Contributors:	中醫學院中醫學系學士班中醫內科學科;中國附醫基因醫學部
Keywords:	Graves' Ophthalmopathy;CD80;CD86;polymorphism
Date:	2011-03
Issue Date:	2012-03-14
Publisher:	中國醫藥大學
Abstract:	Objective: The aim of this study was to evaluate whether B7 molecules (CD80 and CD86) could be used as genetic markers for the development of Graves’ ophthalmopathy (GO). Design: Cross-sectional study. Participants: 471 patients with Graves’ disease (GD) (200 patients with GO and 271 patients without GO) in a Chinese population in Taiwan. Method: GO was identified by an endocrinologist with substantial experience in thyroid diseases. Blood samples were taken for DNA extraction from GD subjects. The gene polymorphism of CD80 and CD86 was genotype by polymerase chain reaction in each patient. Main outcome measurement: Genotypes of CD80 and CD86 polymorphism. Results: We found that the frequency of C allele at position rs_9831894 of the CD86 gene is statistically different in patients with GD (with and without GO; chi square test: p = 0.0017). In addition, the multifactor dimensionality reduction method was used to identify the best gene-gene interaction to predict the risk of GO. We identified an interaction between CD80_rs9289131 and CD86_rs9872483 (sign test, p = 0.0010). Moreover, the GA haplotype was shown to have a protective effect in the development of ophthalmopathy among patients with GD (odds ratio = 0.63; 95% Confidence Interval: 0.44, 0.90). Moreover, among patients with 58 GO, the patients carrying the GA haplotype had a lower level of free thyroxine T4 than those not carrying the GA haplotype (p = 0.0001). Conclusions: These results suggest that the polymorphisms of the CD86 gene may be used as genetic markers for making the diagnosis and prognosis of GO. GO could be a disease with complex genetic factors, resulting from the existing gene-gene interaction found in the present study.
Relation:	OPHTHALMOLOGY 118(3):553-557
Appears in Collections:	[School of Chinese Medicine] Journal articles

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