多取代萘化合物之新合成法開發

CMUR > College of Pharmacy > School of Pharmacy/Master Degree Program, Ph. D program > Theses & dissertations > Item 310903500/41468

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Title:	多取代萘化合物之新合成法開發 A Novel Synthesis of Substituted Naphthalenes
Authors:	張偉昱
Contributors:	藥學系碩士班
Keywords:	萘化合物；疊氮化合物；Curtius 重排；電子環化反應 naphthalene；azide；Curtius rearrangement；electronic cyclization
Date:	2011-07-26
Issue Date:	2011-10-17 17:03:44 (UTC+8)
Publisher:	中國醫藥大學
Abstract:	萘環化合物一直是許多藥理學者專注研究的骨架之一，目前在藥物方面的領域中已經被廣泛的應用。在藥理學方面，萘環骨架被證實具有很強的生物活性，而且含多取代基團的萘環化合物一般都具有其特殊的生物活性，已用於許多疾病的治療上，如應用在抗癌、抗瘧疾等方面。由於萘環化合物在藥理學的領域有著相當重要的應用，因此，我們設計利用 4,5-二苯基-2,4-戊二烯醯基疊氮化合物經 Curtius 重排及分子內電子環化反應來合成一系列 2-苯基萘化合物，而其反應機構一併探討於此。 For many years naphthalenes have been an interesting structural class of compounds, which have found many uses in the field of medicinal chemistry. In pharmaceuticals, it was confirmed that naphthalenes have good biological actives targeted towards various therapeutic endpoints. For example, the highly substituted naphthalenes are biological active with anticancer and anti-malaria effects. Due to its wide applications in the field of pharmaceuticals, this type of compounds has attracted our attention. We developed an efficient method to synthesize 2-phenyl naphthalenes from 4,5-diphenyl-penta-2,4-dienoyl azides via Curtius rearrangement followed by intramolecular electronic cyclization. A series of 2-phenyl naphthalenes was synthesized, and the mechanism was also discussed herein.
Appears in Collections:	[School of Pharmacy/Master Degree Program, Ph. D program] Theses & dissertations

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