| 摘要: | 摘要
研究背景
臉部情緒知覺在社交技巧上是非常重要的，然而其分子訊息路徑目前並不清楚。MET /AKT 訊息傳導路徑會影響神經發育且與自閉症患者臉部情緒知覺能力有關。本研究主要探討MET /AKT 訊息傳導路徑是否對在臉部情緒知覺造成影響。
研究方法
此研究總共納入182健康成人受試者，包含82位男性、100女性。3種MET核苷酸多型性(rs2237717, rs41735, rs42336)與AKT rs1130233進行基因型測定，並評估基因型在受試者的臉部情緒知覺的影響。臉部情緒知覺的評估採用Mayer–Salovey–Caruso Emotional Intelligence Test (MSCEIT)中情緒知覺的臉部測驗進行測試。同時也評估完整的神經認知功能。
研究結果
MET基因rs2237717中，CT 型個案的臉部情緒知覺表現比TT佳(變異數分析p=0.016,共變數分析p=0.018)，與CC型並無差異。帶有最常見MET CGA單套組（頻率50.5%）個案臉部情緒知覺表現比未攜帶者MET CGA單套組佳(p=0.018, df=1, F=5.69, 共變數分析p=0.009)。共變數分析顯示帶有兩組MET CGA個案臉部情緒知覺也比未攜帶者此單套組個案佳(p=0.023)。在MET /AKT交互作用方面，[C攜帶者/G攜帶者]個案表現較TT/AA個案佳 (變異數分析p=0.035, 共變數分析p= 0.015)，即使控制神經認知功能變項下仍達顯著差異（共變數分析p =0.046)。
研究限制
雖然此研究樣本數為中等，但在MET基因與MET /AKT交互作用的統計檢定力分析(power)呈現中等至足夠（large）的檢定力。
研究結論
本研究結果顯示不只有MET可能會對精神病患的臉部情緒知覺產生影響，而且MET /AKT交互作用也會對個案的臉部情緒知覺產生作用。由此顯示MET /AKT訊息傳導路徑對於臉部情緒知覺扮演重要角色。
Abstract
Background
Facial emotion perception is a major social skill but its molecular signal pathway remains unclear. The MET /AKT cascade affects neurodevelopment in general populations and face recognition in patients with autism. This study explores the possible role of MET /AKT cascade in facial emotion perception.
Methods
One hundred and eighty two unrelated healthy volunteers (82 men and 100 women) were recruited. Three single nucleotide polymorphisms (SNP) of MET (rs2237717, rs41735, rs42336) and AKT rs1130233 were genotyped and tested for their effects on facial emotion perception. Facial emotion perception was assessed by the face task of Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT). Thorough neurocognitive functions were also assessed.
Results
Regarding MET rs2237717, individuals with the CT genotype performed better in facial emotion perception than those with TT (p=0.016 by ANOVA, 0.018 by general linear regression model [GLM] to control for age, gender, and education duration), and showed no difference with those with CC. Carriers with the most common MET CGA haplotype (frequency=50.5%) performed better than non-carriers of CGA in facial emotion perception (p=0.018, df=1, F=5.69, p=0.009 by GLM). In MET rs2237717/AKT rs1130233 interaction, the C carrier/G carrier group showed better facial emotion perception than those with the TT/AA genotype (p=0.035 by ANOVA, 0.015 by GLM), even when neurocognitive functions were controlled (p=0.046 by GLM).
Limitations
Although the sample size in this study was only medium, the powers of MET and MET/AKT were medium to large.
Conclusions
To our knowledge, this study is the first one which suggests that genetic factors can affect performance of facial emotion perception. The findings indicate that MET variances and MET/AKT interaction may affect facial emotion perception, implicating that the MET/AKT cascade plays a significant role in facial emotion perception. Further replication studies are needed. |
