中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/407
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    Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/407


    Title: 環糊精包覆中藥牡丹皮之研究與應用;The inclusion complexes of Moutan Cortex extract with cyclodextrin: preparation and application
    Authors: 彭寬嘉;Kuan-Chia Peng
    Contributors: 中國醫藥大學：中國醫學研究所碩士班
    Keywords: 牡丹;皮;丹;皮酚;環糊精;黑色素;包覆作用;Moutan Cortex;paeonol;cyclodextrins;melanin;inclusion
    Date: 2009-07-22
    Issue Date: 2009-08-10 16:01:15 (UTC+8)
    Abstract: 中藥牡丹皮在傳統中醫上具有清熱涼血、活血化瘀、降壓及抗菌美白功效。主要成分為丹皮酚，酚類化合物易揮發也因為親油性、不會水溶，易影響中藥成品穩定。因此尋找適當材料將丹皮酚轉換成不易揮發形式，材料須兼顧不破壞活性成分及不產生副產物。環糊精是澱粉水解後的寡糖分子，特殊的疏水環狀圓桶分子結構，包覆客分子於中間孔洞，形成主客一體複合物質，改變所包覆客體化合物之化學性質、物理性質及生物可利用性。本研究擬利用環糊精包覆技術，來提昇牡丹皮脂溶性成份對水的溶解度，達到奈米水性化之目的。以牡丹皮美白功效作測試，本研究分兩部分探討環糊精包覆的新型中藥製劑之影響。先行牡丹皮粗萃物及丹皮酚的美白測試，再進行牡丹皮粗萃物的環糊精包覆和包覆物分析鑑定及美白測試。本研究實驗證實牡丹皮粗萃包覆奈米藥物已成功製備，並獲得UV及NMR分析儀器鑑定證實其成份，並將粗萃包覆奈米藥物置入水中時，呈現透明水溶液態，證明粗萃包覆奈米藥物具有良好的水溶性。最後將兩組對照，從DPPH test及Tyrosinase inhibition test中且在特定條件下，看到環糊精並未導致牡丹皮粗萃物活性消失。證實環糊精確實可將脂溶性成分包覆並轉換其化學性質，且不影響原本成分的活性與功效。

    Moutan Cortex (Cortex moutan radicis), a widely used traditional Chinese medicine for the treatment of various diseases. A variety of compounds in Mouton Cortex that Paeonol, a major phenolic component. A phenolic extract of Moutan Cortex has been reported to exhibit DPPH radical-scavenging activity. Cyclodextrins (CDs) are a family of cyclic oligosaccharides that are composed of α-1,4-linked glucopyranose subunits. Cyclodextrins are most important. Because of their inclusion complex forming capability, the properties of the materials with which they complex can be modified significantly . The aim of this study was to prepare inclusion complexes of the paeonol that extraction of Moutan Cortex with CD in order to improve their water-solubility, and studied antioxidant activity and tyrosinase inhibition for drug and CD complex. CD complex analied by UV spectrometer and 1H-NMR (Nuclear magnetic resonance). Modified L-Tyrosine method was used to determine tyrosinase inhibition activity. 1,1-diphenyl-2-pricrylhydrazyl (DPPH) radical-scavenging method was used to determine the antioxidant activities ability.
    Appears in Collections:[Graduate Institute of Chinese Medical Science] Theses & dissertations

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