降解性神經導管摻合中藥對神經再生的研究評估;Evaluation of Biodegradable Nerve Conduits Blended with  Traditional Chinese Medicine on Nerve Regeneration

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题名:	降解性神經導管摻合中藥對神經再生的研究評估;Evaluation of Biodegradable Nerve Conduits Blended with Traditional Chinese Medicine on Nerve Regeneration
作者:	賴彥良;Yen-Liang Lai
贡献者:	中國醫藥大學：中國醫學研究所碩士班
关键词:	神經再生;生物降解性神經導管;中藥;小蘗鹼;明膠;戊二醛;Nerve regeneration;Biodegradable nerve conduit;Traditional Chinese Medicine;Berberine;Gelatin;Glutaraldehyde
日期:	2009-06-11
上传时间:	2009-08-10 16:01:02 (UTC+8)
摘要:	神經導管接合術是應用生物或非生物的材料製成導管橋接兩神經斷端，讓神經導管可以支撐再生神經組織，導引神經軸突沿著管腔從近端長入遠端，神經導管可提供和維持軸突生長所需的環境、防止結締組織進入形成瘢痕。生物可降解性導管可以避免二次手術取出，減少手術風險。結合中藥及生物醫學材料提供了神經再生的一種新方法。本研究以戊二醛交聯明膠並與中藥(小蘗鹼)混合製作降解性神經導管。在細胞實驗中我們發現小蘗鹼對細胞活性有增加的趨勢；藥物釋放實驗中利用分光光度計檢測，可維持至少20天持續釋放藥物；在動物實驗方面，植入七週後的神經再生切片中可看出實驗組的神經再生單元、軸突、許旺細胞和血管明顯較對照組多。 A nerve bridge technique is the introduction of both ends of the injured nerve stumps into a tubular chamber, which can offer the advantages of minimizing invasion and scarring of the nerve. Biodegradable nerve conduits can avoid the damaging problem of re-operation after embedding the conduit. Application of blending traditional chinese medicine and biomedical material to nerve regeneration is a new approach. This study evaluated peripheral nerve regeneration using a biodegradable nerve conduit, which was composed of glutaraldehyde cross-linked gelatin and blended with traditional chinese medicine (Berberine). In the cell culture test, we found that the berberine could be an effective accelerator for Schwann cells proliferation. The amount of berberine released from biodegradable nerve conduit was analyzed by Spectrophotometer and the test extended for 20 days at least. Histological observation showed that more axons and schwann cells had crossed through and beyond the gap region after 7 weeks of implantation. These results indicate the superiority of the biodegradable nerve conduits blended with traditional chinese medicine and not only be an effective aids for regenerating nerves but can also lead to favorable nerve functional recovery.
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