Association of interleukin-18 gene polymorphism with asthma in Chinese patients

CMUR > College of Medicine > School of Medicine > Journal articles > Item 310903500/3717

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/3717

Title:	Association of interleukin-18 gene polymorphism with asthma in Chinese patients
Authors:	李正淳(Cheng-Chun Lee);林維勇(Wei-Yong Lin);萬磊(Lei Wan);蔡育勳;蔡長海(Chang-Hai Tsai);黃春明(Chung-Ming Huang);(Chih-Ping Chen);蔡輔仁(Fuu-Jen Tsai)*
Contributors:	醫學院醫學系學士班神經學科;中國附醫神經部
Keywords:	asthma;interleukin-18 (IL-18);single nucleotide polymorphisms (SNPs)
Date:	2008-01
Issue Date:	2009-08-20 18:49:43 (UTC+8)
Abstract:	Like other allergic diseases, asthma results from multiple conditions. Asthmatic beginning and severity are mediated by both environmental and genetic factors. In asthma studies, important work is realization of the genetic background and identification of genetic factors resulting in asthma development and phenomena. Here, we investigated whether interleukin (IL)-18 single nucleotide polymorphisms (SNPs) are involved in Chinese asthma patients. IL-18 (IL-18) SNP was detected by polymerase chain reaction (PCR)-based restriction analysis in 201 patients with asthma and 60 normal controls. Significant differences were found in the genotype distribution of IL-18 SNP between asthma patients and controls (P=0.000003). Allelic frequency of the IL-18 gene distinguished asthma patients from controls (P=0.000066). The results revealed a significant difference between asthma patients and normal controls in IL-18 SNP and a statistical correlation between IL-18 polymorphisms (105A/C) and asthma formation. We concluded that Chinese who carry the C/C homozygote of the IL-18-105A/C gene polymorphism in coding regions may have a higher risk of developing asthma.
Relation:	JOURNAL OF CLINICAL LABORATORY ANALYSIS22(1):39~44
Appears in Collections:	[School of Medicine] Journal articles

Files in This Item:

File	Size	Format
	0Kb	Unknown	515	View/Open

Loading...