中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/3677
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    题名: Impaired Salivary Function in Patients with Noninsulin-Dependent Diabetes Mellitus with Xerostomia
    作者: 林正介(Cheng-Chieh Lin);孫盛生(Shung-Shung Sun);高嘉鴻(Chia-Hung Kao);李正淳(Cheng-Chun Lee)
    贡献者: 醫學院醫學系學士班家庭醫學科;中國附醫社區醫學部家庭醫學科
    关键词: Salivary function;Noninsulin-dependent diabetes mellitus;Xerostomia
    日期: 2002
    上传时间: 2009-08-20 18:49:13 (UTC+8)
    摘要: To test this hypothesis, salivary function was measured by quantitative salivary scintigraphy in noninsulin-dependent diabetes mellitus (NIDDM) patients, as well as in age- and sex-matched controls for comparison. Seventy-two patients with NIDDM history of over 10 years and 36 healthy age- and sex-matched controls were enrolled in the study. All of the 72 NIDDM patients had good blood sugar control. None presented with autonomic neuropathy. These 72 NIDDM patients were separated into two subgroups. Group 1: 36 patients with xerostomia and Group 2: 36 patients without xerostomia. After intravenous injection of 5mCi Tc-99m pertechnetate, sequential images at 1 min/frame were acquired for 30 min. The 1st and 15th minute uptake ratios (UR) were calculated from the tracer uptakes in the four major salivary glands over the background regions of interest. Saliva excretion was stimulated by one tablet of 200 mg ascorbic acid given orally 15-min postinjection of the tracer. Then, the maximal excretion ratios (ER) of the four major salivary glands after sialagogue stimulation were calculated. Significantly poorer salivary function was found, represented by significantly decreased UR and ER values, in 36 NIDDM patients with xerostomia, when compared with 36 NIDDM patients without xerostomia and 36 healthy controls, via objective and quantitative salivary scintigraphy. It has been speculated that impaired salivary function contributes to NIDDM with xerostomia. However, further studies with a larger series of NIDDM patients are necessary to confirm our findings.
    關聯: JOURNAL OF DIABETES AND ITS COMPLICATIONS 16(2):176~179
    显示于类别:[醫學系] 期刊論文

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