Efficacy and Safety of Monascus purpureus Went Rice in Subjects with Hyperlipidemia.

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Title:	Efficacy and Safety of Monascus purpureus Went Rice in Subjects with Hyperlipidemia.
Authors:	林正介(Lin,Cheng-Chieh);李采娟(Tsai-Chung Li);賴明美(Ming-May Lai)*
Contributors:	醫學院醫學系學士班家庭醫學科;中國附醫社區醫學部家庭醫學科
Date:	2005-11
Issue Date:	2009-08-20 18:49:12 (UTC+8)
Abstract:	Objective: The purpose of this study was to assess the lipid-lowering effect of Monascus purpureus Went rice on serum lipids in patients with hyperlipidemia, and to assess its safety by reporting adverse events and clinical laboratory measurements. Design and methods: This was a randomized, double-blind, placebo-controlled study. In all, 79 patients (aged 23–65 years) with a mean baseline low-density lipoprotein cholesterol (LDL-C) level of 5.28 mmol/l (203.9 mg/dl) received a twice daily dose of placebo or Monascus purpureus Went rice (600 mg) for 8 weeks. Results: At week 8, Monascus purpureus Went rice therapy reduced LDL-C by 27.7%, total cholesterol by 21.5%, triglycerides by 15.8% and apolipoprotein B by 26.0%. High-density lipoprotein cholesterol and apolipoprotein A-I levels were increased by 0.9 and 3.4% respectively (not significant). No patient in the Monascus purpureus Went rice treatment group had an alanine aminotransferase (ALT), aspartate aminotransferase (AST) or creatine phosphokinase (CPK) measurement that was 3 times the upper limit of normal at week 4 and week 8. Conclusion: Monascus purpureus Went rice significantly reduced LDL-C, total cholesterol, triglycerides and apolipoprotein B levels, and was well tolerated in patients with hyperlipidemia. However, this study only provides data from an 8-week trial and long-term safety and efficacy data are needed.
Relation:	EUROPEAN JOURNAL OF ENDOCRINOLOGY 153(5):679~686
Appears in Collections:	[School of Medicine] Journal articles

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