Objective Evidence of Impairment of Alveolar Integrity in Patients with Non-Insulin-Dependent Diabetes Mellitus Using Radionuclide Inhalation Lung Scan

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Title:	Objective Evidence of Impairment of Alveolar Integrity in Patients with Non-Insulin-Dependent Diabetes Mellitus Using Radionuclide Inhalation Lung Scan
Authors:	林正介(Cheng-Chieh Lin)*;張淳堆(Chwen-Tzuei Chang);李采娟(Tsai-Chung Li);高嘉鴻(Chia-Hung Kao)
Contributors:	醫學院醫學系學士班家庭醫學科;中國附醫社區醫學部家庭醫學科
Date:	2002-06
Issue Date:	2009-08-20 18:49:10 (UTC+8)
Abstract:	The alveolar integrity (AI) in 60 patients of noninsulin-dependent diabetes mellitus (NIDDM) who had normal chest X-ray findings and pulmonary function test was measured by technetium-99m (Tc-99m) diethyltriamine pentaacetic acid (DTPA) and Tc-99m hexamethylpropylen amine (HMPAO) radioaerosol inhalation lung scan (lung scan). The degree of AI damage in NIDDM was presented as the clearance rate (%/min) of hydrophilic Tc-99m DTPA and lipophilic Tc-99m HMPAO radioaerosols from the lungs. The AI of NIDDM patients was compared with the AI of 40 normal controls. The results show that (1) the clearance rate of Tc-99m DTPA radioaerosols was faster than those of Tc-99m HMPAO radioareosols in either NIDDM patients or normal controls over any portion of the lungs, (2) the clearance rates of both Tc-99m DTPA and Tc-99m HMPAO radioaerosols were faster in NIDDM patients than those in normal controls over any portion of the lungs. Our findings concluded that (1) at least two different clearance mechanisms of radioaerosols in the lungs are working; and (2) the AI damage in NIDDM patients happened in both hydrophilic and lipophilic parts of the alveoli. In addition, the AI damage found by faster clearance rates of both Tc-99m DTPA and HMPAO radioaerosols may provide the other objective evidence of lung complications in NIDDM patients, which are different from the traditional studies such as chest X-ray or pulmonary function test.
Relation:	LUNG 180(3):181~186
Appears in Collections:	[School of Medicine] Journal articles

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