Influence of Intravenous Drug Abuse on Native Arteriovenous Fistula Thrombosis in Chronic Hemodialysis Patients

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Title:	Influence of Intravenous Drug Abuse on Native Arteriovenous Fistula Thrombosis in Chronic Hemodialysis Patients
Authors:	周哲毅(Che-Yi Chou);曾裕雄(Yu-Hsiung Tseng)*;施純明(Chuen-Ming Shih);黃秋錦(Chiu-Ching Huang);陳偉德(Walter Chen);張武隆(Wu-Long Chang);許哲維(Che-Wei Hsu)
Contributors:	醫學院醫學系學士班內科學科;中國附醫內科部腎臟科
Keywords:	End stage renal disease;Hemodialysis;Intravenous drug abuse;Native arteriovenous fistula;Thrombosis;Vascular access infection
Date:	2008-04
Issue Date:	2009-08-20 18:47:21 (UTC+8)
Abstract:	Abstract: The influence of intravenous drug abuse (IVDA) on native arteriovenous fistula thrombosis (NAT) in chronic hemodialysis patients is unknown. We conducted a retrospective study of 123 chronic hemodialysis patients incarcerated in a male prison in Mid-Taiwan. All patients were dialyzed three times per week, 4 h per session. The development of NAT was compared in patients with a history of IVDA (42, 34.1%) and those without (81, 65.9%). A total of 36 patients experienced one or more NAT episodes in 6 years and 29 (80.6%) of them had a history of IVDA. In these 29 patients, 22 (75.9%) relied on repeated thrombectomy or thrombolysis therapy to maintain patent vascular access. In Kaplan–Meier survival analysis, patients with a history of IVDA were prone to develop NAT (log-rank, P < 0.001). The result of Cox regression suggested that a history of IVDA, independent of diabetes, was associated with the development of NAT. Patients with a history of IVDA, even after IVDA has stopped, were still prone to develop NAT and vascular access infection.
Relation:	THERAPEUTIC APHERESIS AND DIALYSIS12(2):152~156
Appears in Collections:	[School of Medicine] Journal articles

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